KMT2D 突变通过 FBXW7 - NOTCH - MYC / TGF - β 1 轴改变肿瘤诱导的调节性 T 细胞运输促进弥漫性大 B 细胞淋巴瘤的肿瘤进展.
关键词: FBXW7 KMT2D MYC NOTCH TGF-β1 diffuse large B-cell lymphoma regulatory T cells
Mesh : Humans F-Box-WD Repeat-Containing Protein 7 / metabolism genetics Lymphoma, Large B-Cell, Diffuse / genetics metabolism pathology Animals Mutation Mice Female Proto-Oncogene Proteins c-myc / metabolism genetics Male T-Lymphocytes, Regulatory / metabolism DNA-Binding Proteins / metabolism genetics Receptors, Notch / metabolism Middle Aged Cell Line, Tumor Neoplasm Proteins / metabolism genetics Signal Transduction Adult Disease Progression Aged
来 源:
DOI:10.7150/ijbs.93349
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