Abstract：
UNASSIGNED: Rosacea is a common chronic inflammatory skin disorder. Endocrinedisrupting chemicals (EDC) are toxic substances, that may gain entry through the skin and subsequently interfere with hormonal and immune functions. Bisphenol A (BPA) and pentachlorophenol sodium (PCS) are two of these EDCs, incriminated in the pathogenesis of certain inflammatory skin disorders. We aimed to test the hypothesis that exposure to BPA and PCS might be involved in the pathogenesis of rosacea.
UNASSIGNED: This prospective cross-sectional study involved 34 patients with rosacea (18F/16 M; mean age 48.5 ± 11 years) and 34 age and sex-matched healthy controls (20 F/14 M; mean age 48.2 ± 10.2 years). Main anthropometric measures, fasting plasma glucose (FPG), insulin, HOMA-IR, lipids, C-reactive protein (CRP), BPA, and PCS levels were quantified and recorded.
UNASSIGNED: Serum CRP (9.6 ± 3.4 vs. 3.7 ± 1.6 mg/L, respectively, p0.05 for all). Serum BPA levels were 55.8 ± 14.4 and 51.9 ± 19.2 ng/mL, and PCS levels were 63.3 ± 45.9 ng/mL and 68.6 ± 40.8 ng/mL for patients and healthy controls, respectively. There was no significant difference in BPA and PCS levels between the two groups (p > 0.05 for both). No significant association was found among HOMAIR, CRP, BPA, and PCS levels (p > 0.05 for all).
UNASSIGNED: Although the present study fails to provide presumptive evidence for the role of BPA and PCS in rosacea, the question as to other EDCs might be involved in its etiopathogenesis remains. This hypothesis requires confirmation in large-scale future prospective trials.
UNASSIGNED: This prospective cross-sectional study involved 34 patients with rosacea (18F/16 M; mean age 48.5 ± 11 years) and 34 age and sex-matched healthy controls (20 F/14 M; mean age 48.2 ± 10.2 years). Main anthropometric measures, fasting plasma glucose (FPG), insulin, HOMA-IR, lipids, C-reactive protein (CRP), BPA, and PCS levels were quantified and recorded.
UNASSIGNED: Serum CRP (9.6 ± 3.4 vs. 3.7 ± 1.6 mg/L, respectively, p0.05 for all). Serum BPA levels were 55.8 ± 14.4 and 51.9 ± 19.2 ng/mL, and PCS levels were 63.3 ± 45.9 ng/mL and 68.6 ± 40.8 ng/mL for patients and healthy controls, respectively. There was no significant difference in BPA and PCS levels between the two groups (p > 0.05 for both). No significant association was found among HOMAIR, CRP, BPA, and PCS levels (p > 0.05 for all).
UNASSIGNED: Although the present study fails to provide presumptive evidence for the role of BPA and PCS in rosacea, the question as to other EDCs might be involved in its etiopathogenesis remains. This hypothesis requires confirmation in large-scale future prospective trials.
摘要：
■酒渣鼻是一种常见的慢性炎症性皮肤病。内分泌干扰化学物质（EDC）是有毒物质，这可能会通过皮肤进入并随后干扰荷尔蒙和免疫功能。双酚A（BPA）和五氯酚钠（PCS）是其中两种EDC，与某些炎症性皮肤病的发病机理有关。我们旨在检验以下假设：暴露于BPA和PCS可能与酒渣鼻的发病机理有关。
■这项前瞻性横断面研究涉及34名酒渣鼻患者（18F/16M；平均年龄48.5±11岁）和34名年龄和性别匹配的健康对照（20F/14M；平均年龄48.2±10.2岁）。主要人体测量,空腹血糖（FPG），胰岛素，HOMA-IR,脂质，C反应蛋白(CRP),BPA,和PCS水平进行量化和记录。
■血清CRP（9.6±3.4vs.3.7±1.6mg/L,分别,所有p0.05)。血清BPA水平为55.8±14.4和51.9±19.2ng/mL，患者和健康对照组的PCS水平分别为63.3±45.9ng/mL和68.6±40.8ng/mL，分别。两组间BPA和PCS水平差异无统计学意义(均p>0.05)。在HOMAIR之间没有发现显著的关联，CRP,BPA,和PCS水平(全部p>0.05)。
■尽管本研究未能为BPA和PCS在酒渣鼻中的作用提供推定证据，关于其他EDC的问题可能涉及其病因仍然存在。这一假设需要在未来的大规模前瞻性试验中得到证实。
■这项前瞻性横断面研究涉及34名酒渣鼻患者（18F/16M；平均年龄48.5±11岁）和34名年龄和性别匹配的健康对照（20F/14M；平均年龄48.2±10.2岁）。主要人体测量,空腹血糖（FPG），胰岛素，HOMA-IR,脂质，C反应蛋白(CRP),BPA,和PCS水平进行量化和记录。
■血清CRP（9.6±3.4vs.3.7±1.6mg/L,分别,所有p0.05)。血清BPA水平为55.8±14.4和51.9±19.2ng/mL，患者和健康对照组的PCS水平分别为63.3±45.9ng/mL和68.6±40.8ng/mL，分别。两组间BPA和PCS水平差异无统计学意义(均p>0.05)。在HOMAIR之间没有发现显著的关联，CRP,BPA,和PCS水平(全部p>0.05)。
■尽管本研究未能为BPA和PCS在酒渣鼻中的作用提供推定证据，关于其他EDC的问题可能涉及其病因仍然存在。这一假设需要在未来的大规模前瞻性试验中得到证实。
