Abstract：
Microbial fermentation has provided fermented foods and important chemicals such as antibiotics, amino acids, and vitamins. Metabolic engineering of synthetic microbes has expanded the range of compounds produced by fermentation. Petroleum-derived aromatic compounds are widely used in industry as raw materials for pharmaceuticals, dyes, and polymers and are in great demand. This review highlights the current efforts in the microbial production of various aromatic chemicals such as aromatic amines, cinnamic acid derivatives, and flavoring aromatics, including their biosynthesis pathways. In addition, the unique biosynthetic mechanism of pyrazine, a heterocyclic compound, from amino acids is described to expand the use of biomass-derived aromatic compounds. I also discuss our efforts to develop high-performance bioplastics superior to petroleum plastics from the aromatic compounds produced by microbial fermentation.
摘要：
微生物发酵提供了发酵食品和重要的化学物质，如抗生素，氨基酸,和维生素。合成微生物的代谢工程扩大了发酵产生的化合物的范围。石油衍生的芳香族化合物在工业中被广泛用作药物的原料，染料，和聚合物，需求量很大。这篇综述强调了目前在各种芳香化学品如芳香胺的微生物生产方面的努力，肉桂酸衍生物，和调味芳香剂，包括它们的生物合成途径。此外,吡嗪独特的生物合成机制，杂环化合物，从氨基酸被描述以扩展生物质衍生的芳族化合物的用途。我还讨论了我们从微生物发酵产生的芳香族化合物中开发优于石油塑料的高性能生物塑料的努力。
