METHODS: In this study, we analyze volumes of various brain regions with the software \"md brain\" based on routine MRI scans of 53 pwMS in a real-world setting. We compare brain volumes of pwMS with an EDSS ≥ 3.5 and a disease duration ≥ 10 years to the brain volumes of pwMS with an EDSS < 3.5 and a disease duration < 10 years as well as with or without immunotherapy.
RESULTS: pwMS with an EDSS ≥ 3.5 and a disease duration ≥ 10 years had significantly lower volumes of the total brain, the grey matter and of the frontal, temporal, parietal and occipital lobe regions as compared to pwMS with an EDSS < 3.5 and a disease duration < 10 years. Regional brain volumes were significantly lower in pwMS without immunotherapy.
CONCLUSIONS: The study showed that higher EDSS, longer disease duration and absence of immunotherapy was associated with lower volumes in a number of brain regions. Further real-world studies may include larger patient cohorts in longitudinal analyses.
方法:在本研究中,我们使用软件“mdbrain”基于53pwMS的常规MRI扫描在现实世界中分析各个大脑区域的体积。我们比较了EDSS≥3.5和疾病持续时间≥10年的pwMS的脑体积与EDSS<3.5和疾病持续时间<10年以及有或没有免疫治疗的pwMS的脑体积。
结果:在EDSS≥3.5和疾病持续时间≥10年的情况下,pwMS的总脑容量显着降低,灰质和额叶,temporal,与PwMS相比,顶叶和枕叶区域EDSS<3.5,疾病持续时间<10年。在没有免疫治疗的情况下,pwMS的局部脑体积显着降低。
结论:研究表明,较高的EDSS,病程延长和缺乏免疫治疗与多个脑区体积减少相关.进一步的现实世界研究可能包括纵向分析中的较大患者队列。