PDF(Pubmed)
Abstract：
BACKGROUND: Atrophy of white and grey matter volumes occurs early in the brains of people with multiple sclerosis (pwMS) and has great clinical relevance. In clinical trials, brain atrophy can be quantified by magnetic resonance imaging (MRI) with automated software tools.
METHODS: In this study, we analyze volumes of various brain regions with the software \"md brain\" based on routine MRI scans of 53 pwMS in a real-world setting. We compare brain volumes of pwMS with an EDSS ≥ 3.5 and a disease duration ≥ 10 years to the brain volumes of pwMS with an EDSS < 3.5 and a disease duration < 10 years as well as with or without immunotherapy.
RESULTS: pwMS with an EDSS ≥ 3.5 and a disease duration ≥ 10 years had significantly lower volumes of the total brain, the grey matter and of the frontal, temporal, parietal and occipital lobe regions as compared to pwMS with an EDSS < 3.5 and a disease duration < 10 years. Regional brain volumes were significantly lower in pwMS without immunotherapy.
CONCLUSIONS: The study showed that higher EDSS, longer disease duration and absence of immunotherapy was associated with lower volumes in a number of brain regions. Further real-world studies may include larger patient cohorts in longitudinal analyses.
METHODS: In this study, we analyze volumes of various brain regions with the software \"md brain\" based on routine MRI scans of 53 pwMS in a real-world setting. We compare brain volumes of pwMS with an EDSS ≥ 3.5 and a disease duration ≥ 10 years to the brain volumes of pwMS with an EDSS < 3.5 and a disease duration < 10 years as well as with or without immunotherapy.
RESULTS: pwMS with an EDSS ≥ 3.5 and a disease duration ≥ 10 years had significantly lower volumes of the total brain, the grey matter and of the frontal, temporal, parietal and occipital lobe regions as compared to pwMS with an EDSS < 3.5 and a disease duration < 10 years. Regional brain volumes were significantly lower in pwMS without immunotherapy.
CONCLUSIONS: The study showed that higher EDSS, longer disease duration and absence of immunotherapy was associated with lower volumes in a number of brain regions. Further real-world studies may include larger patient cohorts in longitudinal analyses.
摘要：
背景：白质和灰质体积的萎缩发生在多发性硬化症（pwMS）患者的大脑早期，具有很大的临床意义。在临床试验中,脑萎缩可以通过磁共振成像(MRI)和自动化软件工具进行量化.
方法：在本研究中，我们使用软件“mdbrain”基于53pwMS的常规MRI扫描在现实世界中分析各个大脑区域的体积。我们比较了EDSS≥3.5和疾病持续时间≥10年的pwMS的脑体积与EDSS<3.5和疾病持续时间<10年以及有或没有免疫治疗的pwMS的脑体积。
结果：在EDSS≥3.5和疾病持续时间≥10年的情况下，pwMS的总脑容量显着降低，灰质和额叶，temporal,与PwMS相比，顶叶和枕叶区域EDSS<3.5，疾病持续时间<10年。在没有免疫治疗的情况下，pwMS的局部脑体积显着降低。
结论：研究表明，较高的EDSS，病程延长和缺乏免疫治疗与多个脑区体积减少相关.进一步的现实世界研究可能包括纵向分析中的较大患者队列。
方法：在本研究中，我们使用软件“mdbrain”基于53pwMS的常规MRI扫描在现实世界中分析各个大脑区域的体积。我们比较了EDSS≥3.5和疾病持续时间≥10年的pwMS的脑体积与EDSS<3.5和疾病持续时间<10年以及有或没有免疫治疗的pwMS的脑体积。
结果：在EDSS≥3.5和疾病持续时间≥10年的情况下，pwMS的总脑容量显着降低，灰质和额叶，temporal,与PwMS相比，顶叶和枕叶区域EDSS<3.5，疾病持续时间<10年。在没有免疫治疗的情况下，pwMS的局部脑体积显着降低。
结论：研究表明，较高的EDSS，病程延长和缺乏免疫治疗与多个脑区体积减少相关.进一步的现实世界研究可能包括纵向分析中的较大患者队列。
