Abstract：
Non-coding RNAs (ncRNAs) belong to a class of untranslated nucleic acids involved in regulation of gene expression. ncRNAs are categorized as small (<200 ribonucleotides in length), i.e., microRNAs (miRNAs), and long ncRNAs (lncRNAs) (200 to thousands of ribonucleotides in length) and circular RNAs (circRNAs). In contrast to miRNAs, the roles of lncRNAs in general and circRNAs in bone metabolism specifically are not well understood. As such, a comprehensive understanding of these RNA species in bone turnover could be of great value in the development of new diagnostic tools and therapeutic targets. Unfortunately, measurement of these unique RNAs lacks standardization, a component critical to clinical translation. This review examines the potential role of lncRNA and circRNA as bone biomarkers, the need for validated and standardized measurement and challenges thereof.
摘要：
非编码RNA(ncRNA)属于一类参与基因表达调控的非翻译核酸。ncRNAs被归类为小（长度<200个核糖核苷酸），即，microRNAs(miRNAs),和长ncRNAs（lncRNAs）（长度为200到数千个核糖核苷酸）和环状RNAs（circularRNAs）。与miRNA相反,lncRNAs在一般和circRNAs在骨代谢中的作用还没有很好的理解。因此，全面了解这些RNA在骨转换中的作用可能对开发新的诊断工具和治疗靶点具有重要价值.不幸的是,这些独特的RNA的测量缺乏标准化，对临床翻译至关重要的组成部分。这篇综述探讨了lncRNA和circRNA作为骨生物标志物的潜在作用，对经过验证和标准化的测量的需求及其挑战。
