Abstract：
Some central nervous system (CNS) malignancies are highly aggressive and urgently need innovative treatment strategies to improve prognosis. A significant concern for therapeutic development is the time-consuming nature of developing treatments for CNS tumors. Therefore, a rapid and efficient translational approach is needed to address this problem. Translational and reverse translational research aims to bridge the gap between laboratory data and clinical applications and has been developed in the field of neuro-oncology. This study presents our translational platform systems for malignant CNS tumors, which combine an intraoperative integrated diagnostic system and comprehensive in vitro and in vivo assay systems. These laboratory systems may contribute to a better understanding of tumor biology and the development of novel therapeutic strategies for the poor prognosis of CNS tumors.
摘要：
一些中枢神经系统（CNS）恶性肿瘤具有高度侵袭性，迫切需要创新的治疗策略来改善预后。治疗开发的一个重要问题是开发CNS肿瘤治疗的耗时性质。因此,需要一种快速有效的翻译方法来解决这个问题。翻译和反向翻译研究旨在弥合实验室数据和临床应用之间的差距，并已在神经肿瘤学领域发展起来。这项研究提出了我们的转化平台系统，用于恶性中枢神经系统肿瘤，它结合了术中综合诊断系统和全面的体外和体内测定系统。这些实验室系统可能有助于更好地了解肿瘤生物学和开发新的治疗策略，以治疗中枢神经系统肿瘤的不良预后。
