Abstract：
Lipid-lowering therapy plays a central role in reducing cardiovascular events. Over the past few decades, clinical trials utilizing several imaging techniques have consistently shown that lipid-lowering therapy can reduce the coronary plaque burden and improve plaque composition. Although intravascular ultrasound has been the most extensively used modality to assess plaque burden, other invasive modalities, such as optical coherence tomography and near-infrared spectroscopy, provide relevant data on plaque vulnerability, and computed tomography angiography detects both plaque volume and characteristics non-invasively. A large body of evidence supports the notion that reducing low-density lipoprotein cholesterol using statins combined with ezetimibe and proprotein convertase subtillisin/kexin type 9 inhibitors consistently shows improvements in plaque burden and favorable morphological changes. This review summarizes previously obtained data on the impact of lipid-lowering treatment strategies on atherosclerotic plaque regression, as assessed using several imaging modalities.
摘要：
降脂治疗在减少心血管事件中起着重要作用。在过去的几十年里，利用多种成像技术的临床试验一致表明,降脂治疗可以减轻冠状动脉斑块负担并改善斑块组成.尽管血管内超声是最广泛使用的评估斑块负荷的方法,其他侵入性模式，如光学相干层析成像和近红外光谱，提供有关斑块易损性的相关数据，和计算机断层扫描血管造影非侵入性地检测斑块体积和特征。大量证据支持以下观点：使用他汀类药物与依泽替米贝和前蛋白转化酶subtilisin/kexin9型抑制剂联合使用降低低密度脂蛋白胆固醇始终显示出斑块负担的改善和有利的形态学变化。这篇综述总结了先前获得的关于降脂治疗策略对动脉粥样硬化斑块消退的影响的数据。使用几种成像方式进行评估。
