Abstract：
An increasing number of people undergo anesthesia and surgery. Perioperative neurocognitive and depressive disorders are common central nervous system complications with similar pathogeneses. These conditions pose a deleterious threat to human health and a significant societal burden. In recent years, numerous studies have focused on the role of the gut microbiota and its metabolites in the central nervous system via the gut-brain axis. Its involvement in perioperative neurocognitive and depressive disorders has attracted considerable attention. This review aimed to elucidate the role of the gut microbiota and its metabolites in the pathogenesis of perioperative neurocognitive and depressive disorders, as well as the value of targeted interventions and treatments.
摘要：
越来越多的人接受麻醉和手术。围手术期神经认知障碍和抑郁症是常见的中枢神经系统并发症，具有相似的病因。这些状况对人类健康构成了有害威胁,并造成了重大的社会负担。近年来,许多研究集中在肠道微生物群及其代谢产物通过肠-脑轴在中枢神经系统中的作用。其参与围手术期神经认知和抑郁障碍引起了相当多的关注。本文旨在阐明肠道菌群及其代谢产物在围手术期神经认知和抑郁障碍发病机制中的作用。以及有针对性的干预和治疗的价值。
