METHODS: This study aimed to evaluate plasma responses of FGF21 to an alcohol challenge in three groups: 15 males with AUD, 15 healthy males with a father with AUD (Predisposed) and 15 healthy males without any predisposition to AUD (Controls). All participants were investigated after an overnight fast. Assessments, including blood sampling and visual analog scale-assessed desire for alcohol intake, were performed before and for 10 hours after ingesting 0.5 g alcohol per kg body weight over 10 minutes.
RESULTS: The three groups were age and body-mass index-matched and had normal plasma concentrations of transaminases and FibroScan®-assessed elastography. Baseline FGF21 concentrations did not differ between groups, but individuals with AUD exhibited greater FGF21 responses to alcohol (area under the curve (AUC0-600 min): 954 ± 665 ng/ml × min (mean (standard deviation)) compared to Controls (AUC0-600 min: 453 ± 333 ng/ml × min, P = 0.03) but not Predisposed (AUC0-600 min: 556 ± 429 ng/ml × min, P = 0.11).
CONCLUSIONS: In conclusion, we demonstrate greater alcohol-induced FGF21 responses in individuals with AUD compared to healthy individuals without paternal predisposition to AUD, suggesting a role for FGF21 in AUD pathophysiology.
方法:本研究旨在评估三组FGF21对酒精攻击的血浆反应:15名男性,AUD,15名健康男性,父亲有AUD(易感),15名健康男性没有任何AUD倾向(对照)。所有参与者在过夜禁食后进行了调查。评估,包括血液采样和视觉模拟量表评估对酒精摄入的渴望,在10分钟内每公斤体重摄入0.5g酒精之前和之后进行10小时。
结果:三组的年龄和体重指数匹配,血浆转氨酶和FibroScan®评估弹性成像的浓度正常。基线FGF21浓度在组间没有差异,但与对照组(AUC0-600分钟:453±333ng/ml×min,曲线下面积(AUC0-600分钟):954±665ng/ml×min(平均值(标准偏差)))相比,具有AUD的个体对酒精表现出更大的FGF21反应,P=0.03),但不倾向于(AUC0-600min:556±429ng/ml×min,P=0.11)。
结论:结论:我们证明,与没有父亲对AUD易感性的健康个体相比,在AUD个体中酒精诱导的FGF21反应更大,提示FGF21在AUD病理生理学中的作用。