Abstract：
The four main types of biomolecules are nucleic acids, proteins, carbohydrates and lipids. The knowledge about their respective interactions is as important as the individual understanding of each of them. However, while, for example, the interaction of proteins with the other three groups is extensively studied, that of nucleic acids and lipids is, in comparison, very poorly explored. An iconic paradigm of physical (and likely functional) proximity between DNA and lipids is the case of the genomic DNA in eukaryotes: enclosed within the nucleus by two concentric lipid bilayers, the wealth of implications of this interaction, for example in genome stability, remains underassessed. Nuclear lipid-related phenotypes have been observed for 50 years, yet in most cases kept as mere anecdotical descriptions. In this review, we will bring together the evidence connecting lipids with both the nuclear envelope and the nucleoplasm, and will make critical analyses of these descriptions. Our exploration establishes a scenario in which lipids irrefutably play a role in nuclear homeostasis.
摘要：
生物分子的四种主要类型是核酸，蛋白质，碳水化合物和脂质。关于他们各自相互作用的知识与对他们每个人的个人理解一样重要。然而,while,例如,蛋白质与其他三组的相互作用被广泛研究，核酸和脂质是，相比之下,探索得很差。DNA和脂质之间物理（和可能的功能）接近的标志性范例是真核生物中的基因组DNA：由两个同心脂质双层包围在细胞核内，这种互动的丰富含义，例如在基因组稳定性方面，仍然被低估。核脂质相关表型已经观察了50年，然而，在大多数情况下，保持仅仅是反常的描述。在这次审查中,我们将把脂质与核膜和核质联系起来，并将对这些描述进行批判性分析。我们的探索建立了一种情况，其中脂质无可辩驳地在核稳态中起作用。
