Abstract：
RNA-binding protein (RBP) phase separation in oncology reveals a complex interplay crucial for understanding tumor biology and developing novel therapeutic strategies. Aberrant phase separation of RBPs significantly influences gene regulation, signal transduction, and metabolic reprogramming, contributing to tumorigenesis and drug resistance. Our review highlights the integral roles of RBP phase separation in stress granule dynamics, mRNA stabilization, and the modulation of transcriptional and translational processes. Furthermore, interactions between RBPs and non-coding RNAs add a layer of complexity, providing new insights into their collaborative roles in cancer progression. The intricate relationship between RBPs and phase separation poses significant challenges but also opens up novel opportunities for targeted therapeutic interventions. Advancing our understanding of the molecular mechanisms and regulatory networks governing RBP phase separation could lead to breakthroughs in cancer treatment strategies.
摘要：
肿瘤学中的RNA结合蛋白（RBP）相分离揭示了复杂的相互作用，对于理解肿瘤生物学和开发新的治疗策略至关重要。RBPs的异常相分离显著影响基因调控，信号转导，和代谢重编程，有助于肿瘤发生和耐药性。我们的评论强调了RBP相分离在应力颗粒动力学中的整体作用，mRNA稳定，以及转录和翻译过程的调节。此外，RBP和非编码RNA之间的相互作用增加了一层复杂性，为他们在癌症进展中的协作角色提供新的见解。RBP和相分离之间的复杂关系提出了重大挑战，但也为靶向治疗干预开辟了新的机会。提高我们对控制RBP相分离的分子机制和调节网络的理解可能会导致癌症治疗策略的突破。
