细胞因子 Meteorin 样通过破坏线粒体功能来抑制抗肿瘤 CD8 + T 细胞应答。
关键词: CD8(+) T cell hypofunction Meteorin-like protein T cell exhaustion anti-tumor immunity mitochondrial dysfunction
Mesh : CD8-Positive T-Lymphocytes / immunology Animals Mitochondria / metabolism immunology Mice Tumor Microenvironment / immunology Lymphocytes, Tumor-Infiltrating / immunology metabolism Humans Mice, Inbred C57BL Cytokines / metabolism Signal Transduction Energy Metabolism PPAR delta / metabolism Cell Line, Tumor Neoplasms / immunology Glycolysis Mice, Knockout Oxidative Phosphorylation
来 源:
DOI:10.1016/j.immuni.2024.07.003
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