METHODS: We enrolled 64 treatment-seeking ketamine-dependent patients (53 with KNP and 11 with KPP), 37 medication-free patients with schizophrenia, and 80 healthy controls. Blood NFL levels were measured by single molecule array immunoassay.
RESULTS: NFL levels were highest in the KPP subgroup, followed by the KNP subgroup, and then the schizophrenia and control groups (mean ± SD: 24.5 ± 24.7, 12.9 ± 10.9, 9.2 ± 12.2, and 6.2 ± 2.2 pg/mL, respectively), with no significant difference observed between the schizophrenia and control groups.
CONCLUSIONS: We found that KD is associated with higher NFL levels compared to schizophrenia, with the KPP subgroup showing the most consistent alterations. The observation of accentuated neuroaxonal pathology in individuals with KPP implies that this clinical manifestation is associated with a specific neurobiological phenotype, despite prior evidence suggesting syndromal similarity between schizophrenia and KPP.
方法:我们招募了64名寻求治疗的氯胺酮依赖患者(53名KNP和11名KPP),37名精神分裂症患者不用药,和80个健康对照。通过单分子阵列免疫测定来测量血液NFL水平。
结果:NFL水平在KPP亚组中最高,其次是KNP子组,然后是精神分裂症组和对照组(平均值±SD:24.5±24.7、12.9±10.9、9.2±12.2和6.2±2.2pg/mL,分别),精神分裂症组和对照组之间没有显着差异。
结论:我们发现与精神分裂症相比,KD与更高的NFL水平相关,KPP亚组显示最一致的改变。在KPP患者中观察到的神经轴突病变表明,这种临床表现与特定的神经生物学表型有关。尽管先前有证据表明精神分裂症和KPP之间存在综合征相似性。