Abstract：
BACKGROUND: Olfactory stimulation with mastic resin, derived from the Pistacia lentiscus tree, demonstrated a bona fide sialagogic effect in healthy volunteers [1]. Its main volatile compound, α-pinene, also showed this effect. The current study aimed to validate the effect of mastic resin volatiles in chronic dry mouth patients with confirmed decreased saliva secretion.
METHODS: 41 chronic dry mouth patients with decreased unstimulated saliva secretion (<0.25 mL/min) were exposed to mastic resin volatiles as part of the diagnostic routine at the Saliva Clinic of Academic Centre for Dentistry Amsterdam. During their visit, dry-mouth questionnaires were conducted and samples of unstimulated whole saliva, chew-stimulated saliva, acid-stimulated saliva and mastic resin stimulated saliva were collected. Saliva flow rate, spinnbarkeit, pH, ion composition, MUC5B and MUC7 levels in all samples were analyzed.
RESULTS: Salivary flow rates increased by all stimuli when compared to the baseline unstimulated saliva (P<0.001). During olfactory mastic resin stimulation, the salivary spinnbarkeit (P<0.001) and sodium concentration (P<0.01) were increased compared to unstimulated saliva. MUC5B and MUC7 levels were increased during olfactory mastic resin stimulation compared to chew-stimulated saliva (P=0.016 and P<0.001, respectively). Spinnbarkeit correlated positively with MUC5B (R=0.399, P=0.002) and MUC7 levels (R=0.375, P=0.004). Results of dry-mouth questionnaires indicated reduced posterior palate dryness shortly after olfactory mastic resin stimulation (P=0.04).
CONCLUSIONS: Olfactory mastic resin stimulation increased mucous saliva secretion and reduced posterior palate dryness in a group of chronic dry mouth patients. These findings, validated in patients, underscore mastic resin scent as a beneficial and non-invasive sialagogic treatment for clinical applications.
METHODS: 41 chronic dry mouth patients with decreased unstimulated saliva secretion (<0.25 mL/min) were exposed to mastic resin volatiles as part of the diagnostic routine at the Saliva Clinic of Academic Centre for Dentistry Amsterdam. During their visit, dry-mouth questionnaires were conducted and samples of unstimulated whole saliva, chew-stimulated saliva, acid-stimulated saliva and mastic resin stimulated saliva were collected. Saliva flow rate, spinnbarkeit, pH, ion composition, MUC5B and MUC7 levels in all samples were analyzed.
RESULTS: Salivary flow rates increased by all stimuli when compared to the baseline unstimulated saliva (P<0.001). During olfactory mastic resin stimulation, the salivary spinnbarkeit (P<0.001) and sodium concentration (P<0.01) were increased compared to unstimulated saliva. MUC5B and MUC7 levels were increased during olfactory mastic resin stimulation compared to chew-stimulated saliva (P=0.016 and P<0.001, respectively). Spinnbarkeit correlated positively with MUC5B (R=0.399, P=0.002) and MUC7 levels (R=0.375, P=0.004). Results of dry-mouth questionnaires indicated reduced posterior palate dryness shortly after olfactory mastic resin stimulation (P=0.04).
CONCLUSIONS: Olfactory mastic resin stimulation increased mucous saliva secretion and reduced posterior palate dryness in a group of chronic dry mouth patients. These findings, validated in patients, underscore mastic resin scent as a beneficial and non-invasive sialagogic treatment for clinical applications.
摘要：
背景：用乳香树脂刺激嗅觉，源自黄连木树，在健康志愿者中表现出真正的教育效果[1]。它的主要挥发性化合物，α-pine烯,也显示了这种效果。本研究旨在验证乳香树脂挥发物在慢性口干患者中的作用，并证实唾液分泌减少。
方法：在阿姆斯特丹牙科学术中心唾液诊所，作为诊断常规的一部分，将41例未刺激唾液分泌减少（<0.25mL/min）的慢性口干患者暴露于乳香树脂挥发物。在访问期间,进行口干问卷调查，并采集未刺激的全唾液样本，咀嚼刺激的唾液，收集酸刺激的唾液和乳香树脂刺激的唾液。唾液流速,spinnbarkeit，pH值,离子成分，分析所有样品中的MUC5B和MUC7水平。
结果：与基线未刺激唾液相比，所有刺激都增加了唾液流速（P<0.001）。在嗅觉乳香树脂刺激期间，与未刺激的唾液相比，唾液刺骨肌（P<0.001）和钠浓度（P<0.01）增加。与咀嚼刺激的唾液相比，嗅觉乳香树脂刺激期间MUC5B和MUC7水平增加（分别为P=0.016和P<0.001）。Spinnbarkeit与MUC5B（R=0.399，P=0.002）和MUC7（R=0.375，P=0.004）呈正相关。口干问卷调查的结果表明，嗅觉乳香树脂刺激后不久，后腭干燥度降低（P=0.04）。
结论：嗅觉乳香树脂刺激增加了一组慢性口干患者的粘液唾液分泌并减少了后腭干燥。这些发现,在患者中验证，下划线乳香树脂气味作为一种有益的和非侵入性的唾液治疗，用于临床应用。
方法：在阿姆斯特丹牙科学术中心唾液诊所，作为诊断常规的一部分，将41例未刺激唾液分泌减少（<0.25mL/min）的慢性口干患者暴露于乳香树脂挥发物。在访问期间,进行口干问卷调查，并采集未刺激的全唾液样本，咀嚼刺激的唾液，收集酸刺激的唾液和乳香树脂刺激的唾液。唾液流速,spinnbarkeit，pH值,离子成分，分析所有样品中的MUC5B和MUC7水平。
结果：与基线未刺激唾液相比，所有刺激都增加了唾液流速（P<0.001）。在嗅觉乳香树脂刺激期间，与未刺激的唾液相比，唾液刺骨肌（P<0.001）和钠浓度（P<0.01）增加。与咀嚼刺激的唾液相比，嗅觉乳香树脂刺激期间MUC5B和MUC7水平增加（分别为P=0.016和P<0.001）。Spinnbarkeit与MUC5B（R=0.399，P=0.002）和MUC7（R=0.375，P=0.004）呈正相关。口干问卷调查的结果表明，嗅觉乳香树脂刺激后不久，后腭干燥度降低（P=0.04）。
结论：嗅觉乳香树脂刺激增加了一组慢性口干患者的粘液唾液分泌并减少了后腭干燥。这些发现,在患者中验证，下划线乳香树脂气味作为一种有益的和非侵入性的唾液治疗，用于临床应用。
