Abstract：
As individuals age, their hematopoietic stem cells can sporadically acquire genetic mutations, known as clonal hematopoiesis. Although most of these genomic aberrations are of little consequence, particular changes in certain contexts can lead to the development of hematologic malignancies, such as myelodysplastic syndromes and acute myeloid leukemia. Owing to its pervasive extrahematologic interactions, clonal hematopoiesis is a recognized risk factor for and is causally implicated in the development of several chronic diseases of aging and/or inflammation, such as atherosclerotic cardiovascular disease. Here, we provide a review of the diagnosis and clinical implications of clonal hematopoiesis, as well as evolving management strategies in the absence of formal consensus guidelines.
摘要：
随着年龄的增长,它们的造血干细胞可以偶尔获得基因突变，被称为克隆造血。尽管大多数这些基因组畸变都没有什么后果，在某些情况下的特殊变化可能导致血液系统恶性肿瘤的发展，如骨髓增生异常综合征和急性髓细胞性白血病。由于其广泛的血液外相互作用，克隆造血是公认的危险因素，并与衰老和/或炎症等几种慢性疾病的发展有因果关系。如动脉粥样硬化性心血管疾病。这里,我们提供了克隆造血的诊断和临床意义的综述，以及在没有正式共识准则的情况下不断发展的管理策略。
