Abstract：
The executive control process of monitoring information in working memory depends on the mid-dorsolateral prefrontal cortical region (cytoarchitectonic areas 46 and 9/46) in interaction with the hippocampal memory system. Anatomical studies demonstrated strong connectivity between the mid-dorsolateral prefrontal cortex and the medial parietal area PGm that lies on the precuneus. Area PGm is also strongly connected with the attentional system on the lateral inferior parietal lobule (area PG) and the limbic retrosplenial/posterior cingulate region that interacts with the hippocampal memory system. Thus, in terms of anatomical connectivity, area PGm appears to be a critical node for the integration of executive control processing from the prefrontal cortex with the online attentional and memory related processing. This hypothesis was tested in macaque monkeys with the crossed unilateral lesion methodology. A unilateral lesion in the mid-dorsolateral prefrontal cortex was combined with a unilateral lesion in area PGm in the opposite hemisphere. The results demonstrated an impairment on the externally ordered working memory task that assesses the monitoring of information in working memory. Thus, the medial parietal area PGm is a critical node in mediating the functional interaction between the prefrontal region for the executive control process of monitoring information and the memory system.
摘要：
工作记忆中监测信息的执行控制过程取决于与海马记忆系统相互作用的背外侧前额叶皮质区（细胞结构区46和9/46）。解剖学研究表明，中背外侧前额叶皮层与位于前突的内侧顶叶区域PGm之间具有很强的连通性。PGm区也与侧下顶叶小叶（PG区）和与海马记忆系统相互作用的边缘后脾/后扣带回区的注意系统密切相关。因此，在解剖学连接方面，区域PGm似乎是前额叶皮层执行控制处理与在线注意和记忆相关处理整合的关键节点。使用交叉单侧病变方法在猕猴中测试了该假设。中背外侧前额叶皮层的单侧病变与对侧半球PGm区域的单侧病变相结合。结果表明，评估工作记忆中信息监测的外部有序工作记忆任务受到损害。因此，顶侧区域PGm是调节前额叶区域之间功能相互作用的关键节点，用于监测信息的执行控制过程和存储系统。
