Abstract：
Mismanagement of hazardous waste (HW) causes severe threats to ecosystems and human health. We conducted a systematic literature review and evaluated the evidence regarding the association between residential exposure to HW and childhood neurobehavioral effects. We consulted international agencies websites and conducted a search on MEDLINE and EMBASE databases by applying a \"Population-Exposure-Comparator-Outcome\" question. The evidence evaluation, based on the quality of the studies and their concordance, was graded in sufficient/limited/inadequate. Documents from international agencies were not found. Of the seventy-five studies screened, nine met the eligibility criteria. Studies agree on the association between residential exposure to HW sites and negative neurodevelopmental effects. The evidence of the association was attributed limited to cognitive and behavioral outcomes, and inadequate to Autism Spectrum Disorder. The evidence was evaluated sufficient for HW sites releasing lead and cognitive disorders. Residential exposure to unsafe HW sites may contribute to childhood neurobehavioral alterations. It is urgent to implement environmental remediation of contaminated sites and counteracting illegal and unsafe HW management practices.
摘要：
危险废物管理不善对生态系统和人类健康造成严重威胁。我们进行了系统的文献综述，并评估了有关居住暴露于HW与儿童神经行为影响之间关联的证据。我们查阅了国际机构网站，并通过应用“人口-暴露-比较-结果”问题对MEDLINE和EMBASE数据库进行了搜索。证据评估，根据研究的质量及其一致性，被分级为足够/有限/不充分。没有找到国际机构的文件。在筛选的75项研究中，九人符合资格标准。研究同意住宅暴露于HW站点与负面神经发育影响之间的关联。这种关联的证据仅限于认知和行为结果，不足以治疗自闭症谱系障碍。对于释放铅和认知障碍的HW站点，评估了足够的证据。住宅暴露于不安全的HW场所可能会导致儿童神经行为改变。迫切需要对受污染的场地实施环境修复，并打击非法和不安全的HW管理做法。
