Abstract：
OBJECTIVE: This study aimed to identify biochemical, hematological, and endocrinological abnormalities in a sample of children and adolescents with underweight AN and atypical AN and to compare these results between the two groups.
METHODS: Based on the 5th BMI-percentile admission, adolescents with underweight AN (n = 520) and atypical AN (n = 255) were included and medical records were reviewed.
RESULTS: Low prealbumin (35%) and neutropenia (39%), and several abnormalities in endocrinological parameters (50%) were the most common alterations found in the whole sample. Compared to the atypical AN group, the underweight AN group had significantly higher frequencies of elevated cholesterol (OR = 2.50; p < 0.001) and alanine aminotransferase (OR = 0.22; p = 0.005) and of reduced insulin-like growth (IGF) factor-1 (OR = 0.29; p < 0.001), T3 (OR = 0.46; p < 0.001), luteinizing hormone (OR = 0.24; p < 0.001), follicle stimulating hormone (OR = 0.58; p = 0.004), and 17b-estradiol (OR = 0.39; p < 0.001). However, other blood parameters showed similar alterations in both groups.
CONCLUSIONS: Both groups showed abnormalities in the same blood parameters, but some abnormal parameters were more common in the underweight AN group. These results suggest that atypical AN and underweight AN could present similar risks of certain medical complications.
METHODS: Based on the 5th BMI-percentile admission, adolescents with underweight AN (n = 520) and atypical AN (n = 255) were included and medical records were reviewed.
RESULTS: Low prealbumin (35%) and neutropenia (39%), and several abnormalities in endocrinological parameters (50%) were the most common alterations found in the whole sample. Compared to the atypical AN group, the underweight AN group had significantly higher frequencies of elevated cholesterol (OR = 2.50; p < 0.001) and alanine aminotransferase (OR = 0.22; p = 0.005) and of reduced insulin-like growth (IGF) factor-1 (OR = 0.29; p < 0.001), T3 (OR = 0.46; p < 0.001), luteinizing hormone (OR = 0.24; p < 0.001), follicle stimulating hormone (OR = 0.58; p = 0.004), and 17b-estradiol (OR = 0.39; p < 0.001). However, other blood parameters showed similar alterations in both groups.
CONCLUSIONS: Both groups showed abnormalities in the same blood parameters, but some abnormal parameters were more common in the underweight AN group. These results suggest that atypical AN and underweight AN could present similar risks of certain medical complications.
摘要：
目的：本研究旨在确定生化，血液学,和内分泌异常在一个样本的儿童和青少年的体重过轻和非典型的AN，并比较这些结果在两组之间。
方法：基于第5个BMI百分位数入院，纳入了体重过轻的AN(n=520)和非典型AN(n=255)青少年,并回顾了医疗记录.
结果：低前白蛋白（35％）和中性粒细胞减少（39％），内分泌参数的几种异常（50％）是整个样本中最常见的改变。与非典型AN组相比，体重过轻的AN组的胆固醇升高（OR=2.50；p<0.001）和丙氨酸氨基转移酶升高（OR=0.22；p=0.005）和胰岛素样生长（IGF）因子-1降低（OR=0.29；p<0.001）的频率显着升高，T3（OR=0.46；p<0.001），黄体生成素（OR=0.24；p<0.001），卵泡刺激素（OR=0.58；p=0.004），和17b-雌二醇(OR=0.39;p<0.001)。然而,其他血液指标在两组中显示相似的改变.
结论：两组均显示相同的血液参数异常，但一些异常参数在体重过轻的AN组中更为常见.这些结果表明，非典型AN和体重过轻的AN可能存在某些医学并发症的相似风险。
方法：基于第5个BMI百分位数入院，纳入了体重过轻的AN(n=520)和非典型AN(n=255)青少年,并回顾了医疗记录.
结果：低前白蛋白（35％）和中性粒细胞减少（39％），内分泌参数的几种异常（50％）是整个样本中最常见的改变。与非典型AN组相比，体重过轻的AN组的胆固醇升高（OR=2.50；p<0.001）和丙氨酸氨基转移酶升高（OR=0.22；p=0.005）和胰岛素样生长（IGF）因子-1降低（OR=0.29；p<0.001）的频率显着升高，T3（OR=0.46；p<0.001），黄体生成素（OR=0.24；p<0.001），卵泡刺激素（OR=0.58；p=0.004），和17b-雌二醇(OR=0.39;p<0.001)。然而,其他血液指标在两组中显示相似的改变.
结论：两组均显示相同的血液参数异常，但一些异常参数在体重过轻的AN组中更为常见.这些结果表明，非典型AN和体重过轻的AN可能存在某些医学并发症的相似风险。
