Abstract：
OBJECTIVE: To compare modified viscotrabeculotomy (VCO-Tbo) to modified trabeculotomy (Tbo) in late-onset primary congenital, juvenile open-angle, steroid-induced, and pigmentary glaucoma.
METHODS: Patients were randomly assigned to VCO-Tbo and Tbo groups in this study. Intraocular pressure (IOP), antiglaucoma medications, and success/failure rates were assessed. A linear mixed model was used to compare the change trend at different follow-up times. Survival time was evaluated using the Kaplan-Meier graph and Log-Rank test.
RESULTS: The mean IOP at 1, 3, and 12 months in the VCO-Tbo group was 14.1 ± 3.1, 15.9 ± 3 and 17 ± 3.1 mmHg, respectively. The mean IOP at the same time points in the Tbo group was 15.9 ± 3.3, 17.6 ± 3.5 and 18.4 ± 3.2 mmHg (P = 0.051, 0.058, 0.088, respectively). The VCO-Tbo group had significantly lower IOP after six months (16.5 ± 4.1 mmHg vs. 18.7 ± 3.8 mmHg; p = 0.031) and by the last visit (16.8 ± 2.1 mmHg vs. 18.8 ± 2 mmHg; p = 0.013). The reduction in the number of medications was significant in both groups compared to baseline (P < 0.001), but there was no significant difference between groups (P = 0.450). The complete and qualified success rate was 43.9% and 34.1% in the VCO-Tbo group and 46.8% and 10.6% in the Tbo group at the final follow-up (p = 0.040, and 0.039, respectively).
CONCLUSIONS: Both procedures are effective in IOP and medication reduction. The survival time and efficacy of modified trabeculotomy can be augmented by injecting cohesive viscoelastic in the Schlemm\'s canal.
METHODS: Patients were randomly assigned to VCO-Tbo and Tbo groups in this study. Intraocular pressure (IOP), antiglaucoma medications, and success/failure rates were assessed. A linear mixed model was used to compare the change trend at different follow-up times. Survival time was evaluated using the Kaplan-Meier graph and Log-Rank test.
RESULTS: The mean IOP at 1, 3, and 12 months in the VCO-Tbo group was 14.1 ± 3.1, 15.9 ± 3 and 17 ± 3.1 mmHg, respectively. The mean IOP at the same time points in the Tbo group was 15.9 ± 3.3, 17.6 ± 3.5 and 18.4 ± 3.2 mmHg (P = 0.051, 0.058, 0.088, respectively). The VCO-Tbo group had significantly lower IOP after six months (16.5 ± 4.1 mmHg vs. 18.7 ± 3.8 mmHg; p = 0.031) and by the last visit (16.8 ± 2.1 mmHg vs. 18.8 ± 2 mmHg; p = 0.013). The reduction in the number of medications was significant in both groups compared to baseline (P < 0.001), but there was no significant difference between groups (P = 0.450). The complete and qualified success rate was 43.9% and 34.1% in the VCO-Tbo group and 46.8% and 10.6% in the Tbo group at the final follow-up (p = 0.040, and 0.039, respectively).
CONCLUSIONS: Both procedures are effective in IOP and medication reduction. The survival time and efficacy of modified trabeculotomy can be augmented by injecting cohesive viscoelastic in the Schlemm\'s canal.
摘要：
目的：比较改良内脏兔骨切开术（VCO-Tbo）和改良小梁切开术（Tbo）在晚发型原发性先天性心脏病中的应用。少年开角，类固醇诱导，和色素性青光眼.
方法：本研究将患者随机分为VCO-Tbo和Tbo组。眼内压(IOP),抗青光眼药物，并评估了成功率/失败率。采用线性混合模型比较不同随访时间的变化趋势。使用Kaplan-Meier图和Log-Rank检验评估存活时间。
结果：VCO-Tbo组1、3和12个月的平均IOP分别为14.1±3.1、15.9±3和17±3.1mmHg，分别。Tbo组相同时间点的平均眼压分别为15.9±3.3、17.6±3.5和18.4±3.2mmHg(P分别为0.051、0.058、0.088)。VCO-Tbo组在六个月后IOP显着降低（16.5±4.1mmHg与18.7±3.8mmHg；p=0.031）和最后一次就诊（16.8±2.1mmHg与18.8±2mmHg；p=0.013）。与基线相比，两组的用药数量均显著减少（P<0.001），但组间差异无统计学意义(P=0.450)。最终随访时，VCO-Tbo组的完全和合格成功率分别为43.9％和34.1％，Tbo组的完全和合格成功率分别为46.8％和10.6％（p=0.040和0.039）。
结论：两种方法均可有效降低眼压和药物治疗。改良小梁切开术的生存时间和疗效可通过在Schlemm管内注射粘性粘弹性材料来提高。
方法：本研究将患者随机分为VCO-Tbo和Tbo组。眼内压(IOP),抗青光眼药物，并评估了成功率/失败率。采用线性混合模型比较不同随访时间的变化趋势。使用Kaplan-Meier图和Log-Rank检验评估存活时间。
结果：VCO-Tbo组1、3和12个月的平均IOP分别为14.1±3.1、15.9±3和17±3.1mmHg，分别。Tbo组相同时间点的平均眼压分别为15.9±3.3、17.6±3.5和18.4±3.2mmHg(P分别为0.051、0.058、0.088)。VCO-Tbo组在六个月后IOP显着降低（16.5±4.1mmHg与18.7±3.8mmHg；p=0.031）和最后一次就诊（16.8±2.1mmHg与18.8±2mmHg；p=0.013）。与基线相比，两组的用药数量均显著减少（P<0.001），但组间差异无统计学意义(P=0.450)。最终随访时，VCO-Tbo组的完全和合格成功率分别为43.9％和34.1％，Tbo组的完全和合格成功率分别为46.8％和10.6％（p=0.040和0.039）。
结论：两种方法均可有效降低眼压和药物治疗。改良小梁切开术的生存时间和疗效可通过在Schlemm管内注射粘性粘弹性材料来提高。
