Abstract：
BACKGROUND: This case report demonstrates the effective clinical application of a 3D-printed, patient-specific polycaprolactone (PCL) resorbable scaffold for staged alveolar bone augmentation.
OBJECTIVE: To evaluate the effectiveness of a 3D-printed PCL scaffold in facilitating alveolar bone regeneration and subsequent dental implant placement.
METHODS: A 46-year-old man with a missing tooth (11) underwent staged alveolar bone augmentation using a patient-specific PCL scaffold. Volumetric bone gain and implant stability were assessed. Histological analysis was conducted to evaluate new bone formation and graft integration.
RESULTS: The novel approach resulted in a volumetric bone gain of 364.69 ± 2.53 mm3, sufficient to reconstruct the original alveolar bone contour and permit dental implant placement. Histological analysis showed new bone presence and successful graft integration across all defect zones (coronal, medial, and apical), with continuous new bone formation around and between graft particles. The dental implant achieved primary stability at 35 Ncm-1, indicating the scaffold\'s effectiveness in promoting bone regeneration and supporting implant therapy. The post-grafting planned implant position deviated overall by 2.4° compared with the initial restoratively driven implant plan pre-bone augmentation surgery. The patient reported low average daily pain during the first 48 h and no pain from Day 3.
CONCLUSIONS: This proof-of-concept underscores the potential of 3D-printed scaffolds in personalized dental reconstruction and alveolar bone regeneration. It marks a significant step forward in integrating additive manufacturing technologies into clinical practice through a scaffold-guided bone regeneration (SGBR) approach. The trial was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12622000118707p).
OBJECTIVE: To evaluate the effectiveness of a 3D-printed PCL scaffold in facilitating alveolar bone regeneration and subsequent dental implant placement.
METHODS: A 46-year-old man with a missing tooth (11) underwent staged alveolar bone augmentation using a patient-specific PCL scaffold. Volumetric bone gain and implant stability were assessed. Histological analysis was conducted to evaluate new bone formation and graft integration.
RESULTS: The novel approach resulted in a volumetric bone gain of 364.69 ± 2.53 mm3, sufficient to reconstruct the original alveolar bone contour and permit dental implant placement. Histological analysis showed new bone presence and successful graft integration across all defect zones (coronal, medial, and apical), with continuous new bone formation around and between graft particles. The dental implant achieved primary stability at 35 Ncm-1, indicating the scaffold\'s effectiveness in promoting bone regeneration and supporting implant therapy. The post-grafting planned implant position deviated overall by 2.4° compared with the initial restoratively driven implant plan pre-bone augmentation surgery. The patient reported low average daily pain during the first 48 h and no pain from Day 3.
CONCLUSIONS: This proof-of-concept underscores the potential of 3D-printed scaffolds in personalized dental reconstruction and alveolar bone regeneration. It marks a significant step forward in integrating additive manufacturing technologies into clinical practice through a scaffold-guided bone regeneration (SGBR) approach. The trial was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12622000118707p).
摘要：
背景：此病例报告证明了3D打印的有效临床应用，患者特异性聚己内酯（PCL）可吸收支架用于分阶段牙槽骨增强。
目的：评估3D打印的PCL支架在促进牙槽骨再生和随后的牙种植体放置方面的有效性。
方法：一名46岁牙齿缺失的男性（11）使用患者特异性PCL支架进行了阶段性牙槽骨增强。评估骨体积增加和植入物稳定性。进行组织学分析以评估新骨形成和移植物整合。
结果：新方法导致骨体积增加为364.69±2.53mm3，足以重建原始牙槽骨轮廓并允许种植牙。组织学分析显示所有缺损区都存在新骨并成功整合移植物（冠状，中间,和顶端)，在移植物颗粒周围和之间连续形成新骨。牙科植入物在35Ncm-1时达到了主要稳定性，表明支架在促进骨再生和支持植入物治疗方面的有效性。移植后计划的植入物位置与最初的恢复驱动的植入物计划前的骨增强手术相比总体偏离2.4°。患者在前48小时内报告了低平均每日疼痛，从第3天开始没有疼痛。
结论：这一概念验证强调了3D打印支架在个性化牙齿重建和牙槽骨再生中的潜力。它标志着通过支架引导的骨再生（SGBR）方法将增材制造技术集成到临床实践中的重要一步。该试验在澳大利亚新西兰临床试验注册中心（ACTRN12622000118707p）注册。
目的：评估3D打印的PCL支架在促进牙槽骨再生和随后的牙种植体放置方面的有效性。
方法：一名46岁牙齿缺失的男性（11）使用患者特异性PCL支架进行了阶段性牙槽骨增强。评估骨体积增加和植入物稳定性。进行组织学分析以评估新骨形成和移植物整合。
结果：新方法导致骨体积增加为364.69±2.53mm3，足以重建原始牙槽骨轮廓并允许种植牙。组织学分析显示所有缺损区都存在新骨并成功整合移植物（冠状，中间,和顶端)，在移植物颗粒周围和之间连续形成新骨。牙科植入物在35Ncm-1时达到了主要稳定性，表明支架在促进骨再生和支持植入物治疗方面的有效性。移植后计划的植入物位置与最初的恢复驱动的植入物计划前的骨增强手术相比总体偏离2.4°。患者在前48小时内报告了低平均每日疼痛，从第3天开始没有疼痛。
结论：这一概念验证强调了3D打印支架在个性化牙齿重建和牙槽骨再生中的潜力。它标志着通过支架引导的骨再生（SGBR）方法将增材制造技术集成到临床实践中的重要一步。该试验在澳大利亚新西兰临床试验注册中心（ACTRN12622000118707p）注册。
