Abstract：
Aim: Breast cancer and its metastases involve high mortality even with advances in chemotherapy. Solid lipid nanoparticles provide a platform for drug delivery, reducing side effects and treatment-induced bone loss. A solid nanoparticle containing doxorubicin was evaluated for its ability to prevent bone loss in a pre-clinical breast cancer model. Methods: We investigated the effects of SLNDox in an aggressive metastatic stage IV breast cancer model, which has some important features that are interesting for bone loss investigation. This study evaluates bone loss prevention potential from solid lipid nanoparticles containing doxorubicin breast cancer treatment, an evaluation of the attenuation of morphological changes in bone tissue caused by the treatment and the disease and an assessment of bone loss imaging using computed tomography and electron microscopy. Results: Chemotherapy-induced bone loss was also observed in tumor-free animals; a solid lipid nanoparticle containing doxorubicin prevented damage to the growth plate and to compact and cancellous bones in the femur of tumor-bearing and healthy animals. Conclusion: The association of solid lipid nanoparticles with chemotherapeutic drugs with proven efficacy promotes the prevention of serious consequences of chemotherapy, reducing tumor progression, increasing quality of life and improving prognosis and survival.
[Box: see text].
[Box: see text].
摘要：
目的：乳腺癌及其转移涉及高死亡率，即使化疗的进展。固体脂质纳米颗粒为药物递送提供平台,减少副作用和治疗引起的骨丢失。评价含有多柔比星的固体纳米颗粒在临床前乳腺癌模型中预防骨丢失的能力。方法：我们研究了SLNDox在侵袭性转移性IV期乳腺癌模型中的作用，其中有一些重要的特点，是有趣的骨质流失调查。这项研究评估了含有阿霉素的固体脂质纳米粒治疗乳腺癌的骨丢失预防潜力，评估由治疗和疾病引起的骨组织形态变化的衰减，并使用计算机断层扫描和电子显微镜评估骨丢失成像。结果：在无肿瘤动物中也观察到化疗诱导的骨丢失；含有阿霉素的固体脂质纳米颗粒可防止对生长板的损害以及对荷瘤动物和健康动物股骨中的致密和松质骨的损害。结论:固体脂质纳米粒与已证实疗效的化疗药物联合,可促进预防化疗的严重后果,减少肿瘤进展，提高生活质量，改善预后和生存。
[方框：见正文]。
[方框：见正文]。
