Abstract：
We analyzed the efficacy and safety of aminoglycosides in a retrospective study of 415 patients with acute appendicitis and 277 patients with acute cholecystitis. The following variables increased the incidence of postoperative complications, defined as surgical site infection, recurrent intraabdominal infection, non-infectious post-operative complication, or death: age (p = 0.016 and 0.011), kidney disease (p = 0.019 and <0.001), and ASA Score (p < 0.001). The type of antibiotic therapy did not have a statistically significant effect on the incidence of postoperative complications in patients with acute appendicitis and cholecystitis (p = 0.561 and 0.547, respectively). A linear regression model showed a higher complication rate in patients with kidney disease (p = 0.014) and neoplasms (p = 0.013); the type of antibiotic therapy did not have a significant effect on the outcome (p = 0.765). There was no statistically significant difference in the post-treatment levels of creatinine in patients treated with aminoglycosides (gentamicin 3 mg/kg once daily) and in those who received other antibiotics (p = 0.75).
摘要：
我们在对415例急性阑尾炎患者和277例急性胆囊炎患者的回顾性研究中分析了氨基糖苷类的疗效和安全性。以下变量增加了术后并发症的发生率，定义为手术部位感染，反复腹腔感染,非感染性术后并发症,或死亡：年龄（p=0.016和0.011），肾脏疾病（p=0.019和<0.001），ASA评分（p<0.001）。抗生素治疗的类型对急性阑尾炎和胆囊炎患者术后并发症的发生率没有统计学意义（分别为p=0.561和0.547）。线性回归模型显示，肾脏疾病（p=0.014）和肿瘤（p=0.013）患者的并发症发生率更高；抗生素治疗的类型对结果没有显着影响（p=0.765）。在接受氨基糖苷类（每天一次庆大霉素3mg/kg）治疗的患者和接受其他抗生素治疗的患者中，肌酐的治疗后水平没有统计学上的显着差异（p=0.75）。
