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Abstract：
BACKGROUND: Chronic kidney disease (CKD) and its associated complications, such as anemia and secondary hyperparathyroidism (SHPT), pose significant challenges to global healthcare systems. This study explores the demographic and clinical characteristics of 284 kidney failure (KF) patients undergoing hemodialysis, in an effort to shed light on the possible association between anemia and SHPT. A proven connection between the two could theoretically influence the management plans for CKD patients, with the hopes of achieving lower morbidity and/or mortality in this patient group.
METHODS: A retrospective, cross-sectional, real-world data analytical study was conducted at a hemodialysis center in Tbilisi, Georgia, encompassing a sample size of n = 284 patients on maintenance hemodialysis. The data analyzed was extracted from patients\' medical records.
RESULTS: According to our results, the prevalence of anemia was strikingly high at 82.04%, underlining its substantial burden within this patient population. Our analysis revealed a notable systemic association between anemia and SHPT, particularly when considering hemodialysis vintage. However, our final analysis model revealed no statistically significant association between anemia and intact parathyroid hormone (iPTH) levels. Conclusion: Our study revealed a significant systemic relationship between anemia and SHPT when hemodialysis duration was considered, despite initial analyses showing no direct association. Future research should focus on longitudinal and multi-center studies to better understand this relationship, aiming to enhance the care and management of CKD patients on hemodialysis.
METHODS: A retrospective, cross-sectional, real-world data analytical study was conducted at a hemodialysis center in Tbilisi, Georgia, encompassing a sample size of n = 284 patients on maintenance hemodialysis. The data analyzed was extracted from patients\' medical records.
RESULTS: According to our results, the prevalence of anemia was strikingly high at 82.04%, underlining its substantial burden within this patient population. Our analysis revealed a notable systemic association between anemia and SHPT, particularly when considering hemodialysis vintage. However, our final analysis model revealed no statistically significant association between anemia and intact parathyroid hormone (iPTH) levels. Conclusion: Our study revealed a significant systemic relationship between anemia and SHPT when hemodialysis duration was considered, despite initial analyses showing no direct association. Future research should focus on longitudinal and multi-center studies to better understand this relationship, aiming to enhance the care and management of CKD patients on hemodialysis.
摘要：
背景：慢性肾脏病（CKD）及其相关并发症，如贫血和继发性甲状旁腺功能亢进（SHPT），对全球医疗保健系统构成重大挑战。这项研究探讨了284例接受血液透析的肾衰竭（KF）患者的人口统计学和临床特征。为了阐明贫血和SHPT之间可能的关联。这两者之间的联系在理论上可以影响CKD患者的管理计划，希望在该患者组中实现较低的发病率和/或死亡率。
方法：回顾性研究，横截面,真实世界的数据分析研究是在第比利斯的血液透析中心进行的，格鲁吉亚,涵盖n=284例维持性血液透析患者的样本量。分析的数据是从患者的医疗记录中提取的。
结果：根据我们的结果，贫血患病率高达82.04%,强调其在这一患者人群中的巨大负担。我们的分析显示，贫血和SHPT之间存在明显的系统性关联，特别是在考虑血液透析时。然而,我们的最终分析模型显示,贫血与完整的甲状旁腺激素(iPTH)水平之间无统计学显著关联.结论：我们的研究表明，当考虑血液透析持续时间时，贫血和SHPT之间存在显著的系统性关系。尽管初步分析显示没有直接关联。未来的研究应该集中在纵向和多中心的研究，以更好地理解这种关系，旨在加强对CKD血液透析患者的护理和管理。
方法：回顾性研究，横截面,真实世界的数据分析研究是在第比利斯的血液透析中心进行的，格鲁吉亚,涵盖n=284例维持性血液透析患者的样本量。分析的数据是从患者的医疗记录中提取的。
结果：根据我们的结果，贫血患病率高达82.04%,强调其在这一患者人群中的巨大负担。我们的分析显示，贫血和SHPT之间存在明显的系统性关联，特别是在考虑血液透析时。然而,我们的最终分析模型显示,贫血与完整的甲状旁腺激素(iPTH)水平之间无统计学显著关联.结论：我们的研究表明，当考虑血液透析持续时间时，贫血和SHPT之间存在显著的系统性关系。尽管初步分析显示没有直接关联。未来的研究应该集中在纵向和多中心的研究，以更好地理解这种关系，旨在加强对CKD血液透析患者的护理和管理。
