PDF(Pubmed)
Abstract：
BACKGROUND: Nasolabial fold (NLF) depression can affect the facial appearance of patients to some extent and increase their psychological burdens. In recent years, autologous fat grafting (AFG) combined with botulinum toxin A (BTX-A) injection (AFG + BTX-A injection) has been gradually applied in the treatment of patients with NLF depression. Although studies have been conducted on the efficacy and safety of AFG + BTX-A injection in treating NLF depression, the experimental design, observational indicators, and sample enrollment criteria vary remarkably, making it difficult to draw convincing and consistent conclusions. Thus, further relevant research is warranted.
OBJECTIVE: To assess the esthetic improvement, efficacy, and safety of AFG + BTX-A injections in patients with NLF depression.
METHODS: This study included 60 patients with NLF depression who were treated in our hospital from February 2019 to April 2021. These patients were categorized into control (n = 30) and observation (n = 30) groups. The observation group received AFG + BTX-A injection, whereas the control group underwent AFG only. All patients were evaluated using the wrinkle severity rating scale (WSRS) and global aesthetic improvement scale. The compactness of facial contours, skin evaluation indexes, adverse reactions, and satisfaction of the two groups were evaluated 3 months postoperatively.
RESULTS: The WSRS scores of the observation group at 1, 3, and 6 months postoperatively were lower than those of the control group (P < 0.05). Three months postoperatively, facial fine lines and pores showed obvious improvement and the skin index score was higher in the observation group than in the control group (P < 0.05). The compactness of facial contours was better in the observation group than in the control group (P < 0.05). In addition, no remarkable differences were noted in the incidence of postoperative adverse reactions such as facial stiffness, facial asymmetry, facial bruising, and facial concavity inequality (P > 0.05).
CONCLUSIONS: AFG + BTX-A injection is a highly safe, cost-effective, effective, and long-lasting treatment for NLF depression with high esthetic value, which should be promoted in the future.
OBJECTIVE: To assess the esthetic improvement, efficacy, and safety of AFG + BTX-A injections in patients with NLF depression.
METHODS: This study included 60 patients with NLF depression who were treated in our hospital from February 2019 to April 2021. These patients were categorized into control (n = 30) and observation (n = 30) groups. The observation group received AFG + BTX-A injection, whereas the control group underwent AFG only. All patients were evaluated using the wrinkle severity rating scale (WSRS) and global aesthetic improvement scale. The compactness of facial contours, skin evaluation indexes, adverse reactions, and satisfaction of the two groups were evaluated 3 months postoperatively.
RESULTS: The WSRS scores of the observation group at 1, 3, and 6 months postoperatively were lower than those of the control group (P < 0.05). Three months postoperatively, facial fine lines and pores showed obvious improvement and the skin index score was higher in the observation group than in the control group (P < 0.05). The compactness of facial contours was better in the observation group than in the control group (P < 0.05). In addition, no remarkable differences were noted in the incidence of postoperative adverse reactions such as facial stiffness, facial asymmetry, facial bruising, and facial concavity inequality (P > 0.05).
CONCLUSIONS: AFG + BTX-A injection is a highly safe, cost-effective, effective, and long-lasting treatment for NLF depression with high esthetic value, which should be promoted in the future.
摘要：
背景：鼻唇沟（NLF）凹陷会在一定程度上影响患者的面部外观并增加其心理负担。近年来,自体脂肪移植(AFG)联合肉毒毒素A(BTX-A)注射(AFG+BTX-A注射)已逐渐应用于NLF抑郁患者的治疗。尽管已经对AFG+BTX-A注射液治疗NLF抑郁症的疗效和安全性进行了研究，实验设计，观测指标,样本注册标准差异很大，很难得出令人信服和一致的结论。因此，需要进一步的相关研究。
目的：为了评估美学改善，功效,NLF抑郁症患者注射AFG+BTX-A的安全性。
方法：本研究纳入我院2019年2月至2021年4月收治的60例NLF抑郁症患者。这些患者分为对照组（n=30）和观察组（n=30）。观察组给予AFG+BTX-A注射液,而对照组仅接受AFG。采用皱纹严重程度评定量表(WSRS)和整体美学改善量表对所有患者进行评价。面部轮廓的紧凑性，皮肤评价指标，不良反应,术后3个月评价两组患者的满意度。
结果：观察组术后1、3、6个月的WSRS评分均低于对照组(P<0.05)。术后三个月,观察组面部细纹、毛孔改善明显,皮肤指数评分高于对照组(P<0.05)。观察组面部轮廓紧密度优于对照组(P<0.05)。此外,术后不良反应如面部僵硬的发生率没有显着差异，面部不对称，面部瘀伤,和面部凹度不等式(P>0.05)。
结论：AFG+BTX-A注射液是一种高度安全的，成本效益高,有效,对NLF抑郁症的长期治疗具有较高的美学价值，未来应该推广。
目的：为了评估美学改善，功效,NLF抑郁症患者注射AFG+BTX-A的安全性。
方法：本研究纳入我院2019年2月至2021年4月收治的60例NLF抑郁症患者。这些患者分为对照组（n=30）和观察组（n=30）。观察组给予AFG+BTX-A注射液,而对照组仅接受AFG。采用皱纹严重程度评定量表(WSRS)和整体美学改善量表对所有患者进行评价。面部轮廓的紧凑性，皮肤评价指标，不良反应,术后3个月评价两组患者的满意度。
结果：观察组术后1、3、6个月的WSRS评分均低于对照组(P<0.05)。术后三个月,观察组面部细纹、毛孔改善明显,皮肤指数评分高于对照组(P<0.05)。观察组面部轮廓紧密度优于对照组(P<0.05)。此外,术后不良反应如面部僵硬的发生率没有显着差异，面部不对称，面部瘀伤,和面部凹度不等式(P>0.05)。
结论：AFG+BTX-A注射液是一种高度安全的，成本效益高,有效,对NLF抑郁症的长期治疗具有较高的美学价值，未来应该推广。
