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Abstract：
Regeneration is vital for many organisms, enabling them to repair injuries and adapt to environmental changes. The mechanisms underlying regeneration are complex and involve coordinated events at the cellular and molecular levels. Moreover, while some species exhibit remarkable regenerative capabilities, others, like mammals, have limited regenerative potential. Central to this process is the regulation of gene expression, and among the numerous genes involved, MYC emerges as a regulator of relevant processes during regeneration with roles conserved in several species, including Drosophila. This mini-review aims to provide valuable insights into the regeneration process in flies, focusing on significant organs where the role of MYC has been identified: from the imaginal discs, where MYC regulates cell growth, structure, and proliferation, to the gut, where it maintains the balance between renewal and differentiation of stem cells, and the central nervous system, where it influences the activities of neural stem cells and the interaction between glia and neuronal cells. By emphasizing the molecular mechanisms regulated by MYC, its significance in controlling regeneration mechanisms, and its conserved role in flies, we aim to offer valuable insights into the utility of Drosophila as a model for studying regeneration. Moreover, unraveling MYC\'s function in Drosophila during regeneration may help translate findings into the mechanisms underlying human tissue repair.
摘要：
再生对许多生物体至关重要，使他们能够修复损伤并适应环境变化。再生的潜在机制是复杂的，涉及细胞和分子水平的协调事件。此外，虽然一些物种表现出非凡的再生能力，其他人,像哺乳动物一样，具有有限的再生潜力。这个过程的核心是基因表达的调节，在涉及的众多基因中，MYC在再生过程中作为相关过程的调节剂出现，在几种物种中具有保守的作用，包括果蝇.这篇小型评论旨在为苍蝇的再生过程提供有价值的见解，专注于已经确定MYC作用的重要器官：从想象盘，MYC调节细胞生长，结构,和扩散，对肠道来说，它维持干细胞更新和分化之间的平衡，和中枢神经系统，它影响神经干细胞的活动以及神经胶质和神经元细胞之间的相互作用。通过强调MYC调控的分子机制，它在控制再生机制方面的意义，以及它在苍蝇中的保守作用，我们的目标是提供有关果蝇作为研究再生模型的效用的有价值的见解。此外，在果蝇再生过程中解开MYC的功能可能有助于将发现转化为人体组织修复的潜在机制。
