PDF(Pubmed)
Abstract：
Ion channels are integral membrane proteins mediating ion flow in response to changes in their environment. Among the different types of ion channels reported to date, the super-family of TRP channels stands out since its members have been linked to many pathophysiological processes. The family comprises 6 subfamilies and 28 members in mammals, which are widely distributed throughout most tissues and organs and have an important role in several aspects of cellular physiology. It has been evidenced that abnormal expression, post-translational modifications, and channel trafficking are associated with several pathologies, such as cancer, cardiovascular disease, diabetes, and brain disorders, among others. In this review, we present an updated summary of the mechanisms involved in the subcellular trafficking of TRP channels, with a special emphasis on whether different post-translational modifications and naturally occurring mutagenesis affect both expression and trafficking. Additionally, we describe how such changes have been associated with the development and progress of diverse pathologies associated with the gain or loss of functional phenotypes. The study of these processes will not only contribute to a better understanding the role of TRP channels in the different tissues but will also present novel possible therapeutic targets in diseases where their activity is dysregulated.
摘要：
离子通道是响应于其环境变化而介导离子流的完整膜蛋白。在迄今为止报道的不同类型的离子通道中，TRP通道的超家族突出，因为其成员与许多病理生理过程有关。该家族在哺乳动物中包括6个亚家族和28个成员，它们广泛分布在大多数组织和器官中，在细胞生理学的几个方面具有重要作用。有证据表明，异常表达，翻译后修饰，渠道贩运与几种病理有关，比如癌症，心血管疾病,糖尿病,和脑部疾病，在其他人中。在这次审查中,我们提供了TRP通道亚细胞运输所涉及的机制的最新摘要，特别强调不同的翻译后修饰和自然发生的诱变是否会影响表达和贩运。此外,我们描述了这些变化如何与功能表型的获得或丧失相关的多种病理的发展和进展相关联.对这些过程的研究不仅有助于更好地理解TRP通道在不同组织中的作用，而且还将在其活性失调的疾病中提出新的可能的治疗靶标。
