PDF(Pubmed)
Abstract：
Fanconi syndrome (FS) is a complex disorder characterized by a reabsorption defect in the proximal renal tubule (PT), leading to urinary loss of molecules such as glucose, phosphate, calcium, amino acids, bicarbonate, potassium, and low-molecular-weight proteins. Its etiology can be genetic or acquired, with drug toxicity being a significant cause of the acquired forms. The heterogeneous manifestations of FS, whether in its partial or complete form, can pose challenges in the emergency department; nevertheless, it should be considered in certain patients, as understanding its cause is crucial for initiating effective treatment. We present the case of a 59-year-old female patient with FS who was treated with lenalidomide in the context of stage III IgG kappa multiple myeloma according to the Salmon Durie classification. We highlight the recurrent nature of this syndrome in this patient.
摘要：
Fanconi综合征（FS）是一种复杂的疾病，其特征是近端肾小管（PT）的重吸收缺陷，导致尿液中葡萄糖等分子的流失，磷酸盐,钙，氨基酸,碳酸氢盐,钾，和低分子量蛋白质。其病因可以是遗传的或获得性的,药物毒性是获得性形式的重要原因。FS的异构表现，无论是部分形式还是完整形式，可能会给急诊科带来挑战；尽管如此，应该在某些患者中考虑，因为了解其原因对于开始有效治疗至关重要。我们介绍了根据SalmonDurie分类，在III期IgGκ多发性骨髓瘤的背景下接受来那度胺治疗的59岁女性FS患者的病例。我们强调了该综合征在该患者中的复发性。
