PDF(Pubmed)
Abstract：
UNASSIGNED: During the COVID-19 pandemic, pediatric cases typically exhibit milder symptoms and lower mortality rates. However, the delay in pediatric vaccination poses major risks for children. This multicenter study aimed to comprehensively analyze demographic characteristics, clinical features, disease severity, and risk factors for ICU admission in Iran.
UNASSIGNED: This observational study enrolled children aged 0-21 years with confirmed or probable COVID-19 diagnoses, referred from selected hospitals across 17 counties in Mazandaran province, Iran, between February 19 and August 14, 2021. Patients were categorized into mild, moderate, severe, or critical cases based on clinical and radiographic criteria. Data were extracted from medical records and analyzed using statistical methods. Logistic regression analysis was performed to identify factors associated with ICU admission and disease severity.
UNASSIGNED: Among the 1,031 children included in the study, 61 were diagnosed with MIS-C. The distribution of patients by severity was 156 mild, 671 moderate, and 204 severe/critical cases. Age distribution significantly differed across severity groups (P < 0.001), with 55.19% aged over 5 years and 54% being male. 11.44% had underlying diseases. Fever (71.97%) was the most common symptom, followed by cough (34.43%) and dyspnea (24.83%). Within the inpatient group, 19.77% required ICU admission, with 0.91% mortality, including 3 MIS-C cases. Children with underlying diseases, gastrointestinal symptoms, and obesity had 4.16, 3.10-, and 2.17-times higher likelihood of ICU admission, respectively.
UNASSIGNED: Our study emphasized the importance of recognizing pediatric COVID-19 severity and symptoms. While fever, cough, and dyspnea prevailed, mortality rates were relatively low. However, comorbidities, obesity, and gastrointestinal symptoms linked to ICU admission, stressing early intervention. BMI also impacted disease severity and admission rate. Vaccination and targeted interventions are essential for protecting vulnerable children and easing healthcare strain.
UNASSIGNED: This observational study enrolled children aged 0-21 years with confirmed or probable COVID-19 diagnoses, referred from selected hospitals across 17 counties in Mazandaran province, Iran, between February 19 and August 14, 2021. Patients were categorized into mild, moderate, severe, or critical cases based on clinical and radiographic criteria. Data were extracted from medical records and analyzed using statistical methods. Logistic regression analysis was performed to identify factors associated with ICU admission and disease severity.
UNASSIGNED: Among the 1,031 children included in the study, 61 were diagnosed with MIS-C. The distribution of patients by severity was 156 mild, 671 moderate, and 204 severe/critical cases. Age distribution significantly differed across severity groups (P < 0.001), with 55.19% aged over 5 years and 54% being male. 11.44% had underlying diseases. Fever (71.97%) was the most common symptom, followed by cough (34.43%) and dyspnea (24.83%). Within the inpatient group, 19.77% required ICU admission, with 0.91% mortality, including 3 MIS-C cases. Children with underlying diseases, gastrointestinal symptoms, and obesity had 4.16, 3.10-, and 2.17-times higher likelihood of ICU admission, respectively.
UNASSIGNED: Our study emphasized the importance of recognizing pediatric COVID-19 severity and symptoms. While fever, cough, and dyspnea prevailed, mortality rates were relatively low. However, comorbidities, obesity, and gastrointestinal symptoms linked to ICU admission, stressing early intervention. BMI also impacted disease severity and admission rate. Vaccination and targeted interventions are essential for protecting vulnerable children and easing healthcare strain.
摘要：
■在COVID-19大流行期间，儿科病例通常症状较轻,死亡率较低.然而,儿科疫苗接种的延迟对儿童构成重大风险。这项多中心研究旨在全面分析人口统计学特征，临床特征,疾病严重程度,以及伊朗ICU入院的危险因素。
■这项观察性研究招募了0-21岁确诊或可能确诊为COVID-19的儿童，来自Mazandaran省17个县的选定医院，伊朗,2021年2月19日至8月14日。患者分为轻度，中度,严重,或根据临床和影像学标准的危重病例。从病历中提取数据，并使用统计学方法进行分析。采用Logistic回归分析确定与ICU入住及病情严重程度相关的因素。
■在纳入研究的1031名儿童中，61例被诊断为MIS-C。按严重程度划分的患者分布为156名轻度，671中度，和204例严重/危重病例。严重程度组的年龄分布显着差异（P<0.001），55.19%年龄在5岁以上，54%为男性。11.44%有基础疾病。发热（71.97%）是最常见的症状，其次是咳嗽(34.43%)和呼吸困难(24.83%)。在住院组中，19.77%需要入住ICU，死亡率为0.91%，包括3例MIS-C病例。患有潜在疾病的儿童，胃肠道症状,肥胖有4.16、3.10-，入住ICU的可能性是其2.17倍,分别。
■我们的研究强调了识别儿童COVID-19严重程度和症状的重要性。发烧的时候，咳嗽,呼吸困难盛行，死亡率相对较低.然而,合并症,肥胖，以及与入住ICU相关的胃肠道症状,强调早期干预。BMI也影响疾病的严重程度和入院率。疫苗接种和有针对性的干预措施对于保护弱势儿童和缓解医疗压力至关重要。
■这项观察性研究招募了0-21岁确诊或可能确诊为COVID-19的儿童，来自Mazandaran省17个县的选定医院，伊朗,2021年2月19日至8月14日。患者分为轻度，中度,严重,或根据临床和影像学标准的危重病例。从病历中提取数据，并使用统计学方法进行分析。采用Logistic回归分析确定与ICU入住及病情严重程度相关的因素。
■在纳入研究的1031名儿童中，61例被诊断为MIS-C。按严重程度划分的患者分布为156名轻度，671中度，和204例严重/危重病例。严重程度组的年龄分布显着差异（P<0.001），55.19%年龄在5岁以上，54%为男性。11.44%有基础疾病。发热（71.97%）是最常见的症状，其次是咳嗽(34.43%)和呼吸困难(24.83%)。在住院组中，19.77%需要入住ICU，死亡率为0.91%，包括3例MIS-C病例。患有潜在疾病的儿童，胃肠道症状,肥胖有4.16、3.10-，入住ICU的可能性是其2.17倍,分别。
■我们的研究强调了识别儿童COVID-19严重程度和症状的重要性。发烧的时候，咳嗽,呼吸困难盛行，死亡率相对较低.然而,合并症,肥胖，以及与入住ICU相关的胃肠道症状,强调早期干预。BMI也影响疾病的严重程度和入院率。疫苗接种和有针对性的干预措施对于保护弱势儿童和缓解医疗压力至关重要。
