PDF(Pubmed)
Abstract：
In this News and Views, I discuss our recent publication that established how steroidogenic acute regulatory-related lipid transfer domain-3 (STARD3), a membrane contact protein situated at lysosomal membranes, plays a role in the detoxification of cholesterol hydroperoxide. STARD3\'s methionine residues can be oxidized to methionine sulfoxide by cholesterol hydroperoxide, after which methionine sulfoxide reductases reduce the methionine sulfoxide residues back to methionine. The reaction also results in the reduction of the cholesterol hydroperoxide to an alcohol. The cyclic oxidation and reduction of methionine residues in STARD3 at membrane contact sites creates a catalytically efficient mechanism for detoxification of cholesterol hydroperoxide during cholesterol transport, thus protecting membrane contact sites and the entire cell against the toxicity of cholesterol hydroperoxide.
摘要：
在这个新闻和观点中，我讨论了我们最近的出版物，该出版物建立了类固醇急性调节相关的脂质转移结构域-3（STARD3），一种位于溶酶体膜的膜接触蛋白，在胆固醇过氧化氢的解毒中起作用。STARD3的蛋氨酸残基可以被胆固醇过氧化氢氧化成蛋氨酸亚砜，之后，甲硫氨酸亚砜还原酶将甲硫氨酸亚砜残基还原为甲硫氨酸。该反应还导致胆固醇氢过氧化物还原成醇。STARD3中蛋氨酸残基在膜接触位点的循环氧化和还原为胆固醇运输过程中胆固醇过氧化氢的解毒创造了一种催化有效的机制，从而保护细胞膜接触部位和整个细胞免受胆固醇过氧化氢的毒性。
