Abstract：
BACKGROUND: Patients with permanent hypoparathyroidism experience an impaired quality of life, due to acute and chronic complications that may affect several organs, with an increased risk of hospitalisation and death. Adequate and continuous replacement therapy with calcium and calcitriol is necessary to avoid symptoms and long-term complications related to hypocalcemia.
METHODS: A 63 years old male, affected by permanent post-surgical hypoparathyroidism, was hospitalized in the cardiology department because of a dehiscence of the subcutaneous housing of the double-chambered implantable cardioverter-defibrillator. Chronic replacement therapy for hypoparathyroidism was poorly controlled and, during hospitalization, severe hypocalcemia occurred together with electrocardiographic and echocardiogram life-threatening alterations.
CONCLUSIONS: Constant and targeted long-term replacement therapy with calcium and particularly calcitriol is necessary to avoid major consequences on patients\' health, especially during acute events and in the presence of other comorbidities.
METHODS: A 63 years old male, affected by permanent post-surgical hypoparathyroidism, was hospitalized in the cardiology department because of a dehiscence of the subcutaneous housing of the double-chambered implantable cardioverter-defibrillator. Chronic replacement therapy for hypoparathyroidism was poorly controlled and, during hospitalization, severe hypocalcemia occurred together with electrocardiographic and echocardiogram life-threatening alterations.
CONCLUSIONS: Constant and targeted long-term replacement therapy with calcium and particularly calcitriol is necessary to avoid major consequences on patients\' health, especially during acute events and in the presence of other comorbidities.
摘要：
背景：永久性甲状旁腺功能减退症患者的生活质量受损，由于可能影响多个器官的急性和慢性并发症，住院和死亡的风险增加。为了避免与低钙血症相关的症状和长期并发症，必须使用钙和骨化三醇进行充分和连续的替代疗法。
方法：63岁男性，受永久性术后甲状旁腺功能减退的影响，由于双腔可植入心脏复律除颤器的皮下外壳开裂，在心脏科住院。甲状旁腺功能减退症的慢性替代疗法控制不佳，住院期间,严重的低钙血症伴随着危及生命的心电图和超声心动图改变.
结论：必须使用钙，特别是骨化三醇进行持续和有针对性的长期替代疗法，以避免对患者健康造成重大后果，特别是在急性事件和存在其他合并症的情况下。
方法：63岁男性，受永久性术后甲状旁腺功能减退的影响，由于双腔可植入心脏复律除颤器的皮下外壳开裂，在心脏科住院。甲状旁腺功能减退症的慢性替代疗法控制不佳，住院期间,严重的低钙血症伴随着危及生命的心电图和超声心动图改变.
结论：必须使用钙，特别是骨化三醇进行持续和有针对性的长期替代疗法，以避免对患者健康造成重大后果，特别是在急性事件和存在其他合并症的情况下。
