Abstract：
Regeneration, the complex process of restoring damaged or absent cells, tissues, and organs, varies considerably between species. The zebrafish is a remarkable model organism for its impressive regenerative abilities, particularly in organs such as the heart, fin, retina, spinal cord, and brain. Unlike mammals, zebrafish can regenerate with limited or absent scarring, a phenomenon closely linked to the activation of stem cells and immune cells. This review examines the unique roles played by the immune response and inflammation in zebrafish and mouse during regeneration, highlighting the cellular and molecular mechanisms behind their divergent regenerative capacities. By focusing on zebrafish telencephalic regeneration and comparing it to that of the rodents, this review highlights the importance of a well-controlled, acute, and non-persistent immune response in zebrafish, which promotes an environment conducive to regeneration. The knowledge gained from understanding the mechanisms of zebrafish regeneration holds great promises for the treatment of human neurodegenerative diseases and brain damage (stroke and traumatic brain injuries), as well as for the advancement of regenerative medicine approaches.
摘要：
再生,恢复受损或缺失细胞的复杂过程，组织，和器官，物种之间差异很大。斑马鱼因其令人印象深刻的再生能力而成为一种非凡的模型生物，特别是在心脏等器官中，fin,视网膜,脊髓,和大脑。与哺乳动物不同,斑马鱼可以再生有限或没有疤痕，这种现象与干细胞和免疫细胞的激活密切相关。这篇综述探讨了免疫反应和炎症在斑马鱼和小鼠再生过程中的独特作用。强调其不同再生能力背后的细胞和分子机制。通过关注斑马鱼的端脑再生并将其与啮齿动物的端脑再生进行比较，这次审查强调了控制良好的重要性，急性,斑马鱼的非持续性免疫反应，这促进了有利于再生的环境。从了解斑马鱼再生机制中获得的知识为人类神经退行性疾病和脑损伤（中风和创伤性脑损伤）的治疗带来了巨大的希望，以及再生医学方法的进步。
