Abstract：
This panel was designed to characterize the immune cell landscape in the mouse tumor microenvironment as well as mouse lymphoid tissues (e.g., spleen). As an example, using the MC-38 mouse syngeneic tumor model, we demonstrated that we could measure the frequency and characterize the functional status of CD4 T cells, CD8 T cells, regulatory T cells, NK cells, B cells, macrophages, granulocytes, monocytes, and dendritic cells. This panel is especially useful for understanding the immune landscape in \"cold\" preclinical tumor models with very low immune cell infiltration and for investigating how therapeutic treatments may modulate the immune landscape.
摘要：
该面板旨在表征小鼠肿瘤微环境以及小鼠淋巴组织中的免疫细胞景观（例如，脾）。作为一个例子,使用MC-38小鼠同系肿瘤模型，我们证明了我们可以测量CD4T细胞的频率并表征其功能状态，CD8T细胞，调节性T细胞,NK细胞,B细胞,巨噬细胞，粒细胞,单核细胞,和树突状细胞。该小组对于了解具有非常低的免疫细胞浸润的“冷”临床前肿瘤模型中的免疫景观以及研究治疗性治疗如何调节免疫景观特别有用。
