Abstract：
Sucrose intake is a potential risk factor for non-alcoholic fatty liver disease (NAFLD). Individual characteristics such as sex, play arole in the biological variation of the disease, potentially related to genetic regulation. This research evaluated sex differences in biochemical, histopathological, and gene expression responses associated with NAFLD in C57bl/6N mice on a high sucrose diet. Female and male mice were assigned to control or high sucrose diets (50% sucrose solution) for 20 weeks. After sacrifice, blood and hepatic tissue were collected for analysis. Female mice revealed moderate-to-high NAFLD, whereas male mice showed mild-to-moderate NAFLD. Sex-specific variations were observed in Cd36 gene expression, an upregulation in females compared with the male group, and Adipor1 gene expression showed significant downregulation in the female group in response to high sucrose diet compared with the control group. These findings highlight the importance of considering gender disparities in the treatment and management of NAFLD.
摘要：
蔗糖摄入是非酒精性脂肪性肝病（NAFLD）的潜在危险因素。个体特征，如性别，在疾病的生物学变异中发挥作用，可能与基因调控有关。这项研究评估了生化方面的性别差异，组织病理学,高蔗糖饮食的C57bl/6N小鼠中与NAFLD相关的基因表达反应。将雌性和雄性小鼠分配给对照或高蔗糖饮食(50%蔗糖溶液)20周。牺牲之后,收集血液和肝组织进行分析.雌性小鼠显示中度至高度NAFLD，而雄性小鼠显示轻度至中度NAFLD。在Cd36基因表达中观察到性别特异性变异，与男性组相比，女性的上调，与对照组相比，女性组对高蔗糖饮食的反应和Adipor1基因表达显着下调。这些发现强调了在NAFLD的治疗和管理中考虑性别差异的重要性。
