PDF(Pubmed)
Abstract：
The tumor microenvironment demonstrates great immunophenotypic heterogeneity, which has been leveraged in traditional immune-hot/cold tumor categorization based on the abundance of intra-tumoral immune cells. By incorporating the spatial immune contexture, the tumor immunophenotype was further elaborated into immune-inflamed, immune-excluded, and immune-desert. However, the mechanisms underlying these different immune phenotypes are yet to be comprehensively elucidated. In this review, we discuss how tumor cells and the tumor microenvironment interact collectively to shape the immune landscape from the perspectives of tumor cells, immune cells, the extracellular matrix, and cancer metabolism, and we summarize potential therapeutic options according to distinct immunophenotypes for personalized precision medicine.
摘要：
肿瘤微环境表现出巨大的免疫表型异质性，基于肿瘤内免疫细胞的丰度，在传统的免疫热/冷肿瘤分类中得到了利用。通过结合空间免疫背景，肿瘤免疫表型进一步细化为免疫炎症，免疫排除，和免疫沙漠。然而,这些不同免疫表型的潜在机制尚待全面阐明。在这次审查中,我们从肿瘤细胞的角度讨论了肿瘤细胞和肿瘤微环境如何共同相互作用以塑造免疫景观，免疫细胞，细胞外基质，和癌症代谢，我们根据不同的免疫表型总结了个性化精准医疗的潜在治疗选择。
