PDF(Pubmed)
Abstract：
Activation of astrocytes after sensory stimulation has been reported to be involved in increased blood flow in the central nervous system. In the present study, using a chemogenetic method to induce astrocyte activation in mice without sensory stimulation, we found that astrocytic activation led to increased blood flow in the olfactory bulb, suggesting that astrocyte activation is sufficient for increasing blood flow in the olfactory bulb. The technique established here will be useful for studying the mechanisms underlying sensory input-dependent blood flow increases.
摘要：
据报道，感觉刺激后星形胶质细胞的激活与中枢神经系统血流量增加有关。在本研究中,使用化学遗传学方法在没有感觉刺激的情况下诱导小鼠星形胶质细胞激活，我们发现星形细胞激活导致嗅球血流量增加,这表明星形胶质细胞的激活足以增加嗅球的血流量。此处建立的技术将有助于研究感觉输入依赖性血流量增加的潜在机制。
