Abstract：
The primordial odontogenic tumor (POT) is a rare mixed odontogenic tumor composed of mesenchymal cells, columnar odontogenic epithelium, and fibromyxoid stroma affecting the posterior mandible of children and adolescents. Herein, we report 3 patients with POT and the clinicopathological features of POT previously reported in the literature. A 12-year-old, 19-year-old, and 4-year-old patient presented an asymptomatic swelling in the posterior maxilla and posterior mandible. Imaging exams revealed radiolucent lesions associated with unerupted teeth. The lesions were surgically removed, and the histopathological examination revealed spindle-to-ovoid mesenchymal cells in a fibromyxoid stroma surfaced by columnar odontogenic epithelial cells with reverse nuclear polarization. Deposition of mineralized tissue was observed. The final diagnosis was POT, and patients did not exhibit signs of recurrence. POT should be included in the differential diagnoses of intraosseous lesions in the posterior mandible in pediatric patients.
摘要：
原始牙源性肿瘤(POT)是一种罕见的由间充质细胞组成的混合牙源性肿瘤,柱状牙源性上皮，和纤维粘液样基质影响儿童和青少年的后下颌骨。在这里，我们报告了3例POT患者和先前文献中报道的POT的临床病理特征。一个12岁的孩子,19岁,4岁的患者在上颌骨后部和下颌骨后部无症状肿胀。影像学检查显示与未萌出的牙齿相关的射线可透性病变。手术切除了病灶,组织病理学检查显示，纤维粘液样基质中的梭形至卵圆形间充质细胞由柱状牙源性上皮细胞形成，具有反向核极化。观察到矿化组织的沉积。最后的诊断是POT,患者未出现复发迹象。POT应包括在小儿患者后下颌骨骨内病变的鉴别诊断中。
