PD - L1 在肿瘤来源的外泌体上的表达增强了 α CD3 × α PD - L1 双特异性抗体武装 T 细胞的浸润和抗肿瘤活性。
关键词: Bispecific T-cell engager Exosomal programmed death-ligand 1 Immunotherapy Programmed death-ligand 1
Mesh : Animals Antibodies, Bispecific / pharmacology immunology Exosomes / metabolism immunology Mice B7-H1 Antigen / metabolism antagonists & inhibitors Humans T-Lymphocytes / immunology metabolism Mice, Inbred C57BL Melanoma, Experimental / immunology therapy CD3 Complex / immunology metabolism Lymphocytes, Tumor-Infiltrating / immunology metabolism Cell Line, Tumor Female Cell Movement Xenograft Model Antitumor Assays
来 源:
DOI:10.1007/s00262-024-03785-4
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