Abstract：
HbA1c is a pivotal biomarker in diabetes management, reflecting long-term glycaemic control. HbA1c is often measured with capillary electrophoresis, which generally is a very precise technique, but there can be interference, especially in the case of haemoglobin diseases. Thus, in patients with underlying conditions, the accurate measurement of HbA1c can be challenging. We present a case of special interference in a 74-year-old female patient referred to a HbA1c test, in whom the measurement was thought to be significantly affected by hyperleukocytosis and led to an unexpected diagnosis of leukemic low-grade lymphoma. This case report highlights the underrecognized potential interference of leukocytosis in HbA1c measurement. It underscores the importance of clinical vigilance when interpreting HbA1c results in patients with underlying haematological conditions.
摘要：
HbA1c是糖尿病管理的关键生物标志物，反映长期血糖控制。HbA1c经常用毛细管电泳法测量，这通常是一种非常精确的技术，但是可能会有干扰，尤其是在血红蛋白疾病的情况下。因此，在有潜在疾病的患者中，HbA1c的精确测量可能具有挑战性。我们在一名74岁女性患者中介绍了一例特殊干扰的情况，该患者接受了HbA1c测试，其中的测量被认为受到高白细胞增多的显著影响，并导致白血病低度淋巴瘤的意外诊断。该病例报告强调了白细胞增多在HbA1c测量中的潜在干扰。它强调了在解释患有潜在血液学疾病的患者的HbA1c结果时临床警惕的重要性。
