Abstract：
The strong anti-inflammatory effect of methylprednisolone (MP) is a necessary treatment for various severe cases including acute spinal cord injury (SCI). However, concerns have been raised regarding adverse effects from MP, which also severely limits its clinical application. Natural polyphenols, due to their rich phenolic hydroxyl chemical properties, can form dynamic structures without additional modification, achieving targeted enrichment and drug release at the disease lesion, making them a highly promising carrier. Considering the clinical application challenges of MP, a natural polyphenolic platform is employed for targeted and efficient delivery of MP, reducing its systemic side effects. Both in vitro and SCI models demonstrated polyphenols have multiple advantages as carriers for delivering MP: (1) Achieved maximum enrichment at the injured site in 2 h post-administration, which met the desires of early treatment for diseases; (2) Traceless release of MP; (3) Reducing its side effects; (4) Endowed treatment system with new antioxidative properties, which is also an aspect that needs to be addressed for diseases treatment. This study highlighted a promising prospect of the robust delivery system based on natural polyphenols can successfully overcome the barrier of MP treatment, providing the possibility for its widespread clinical application.
摘要：
甲基强的松龙（MP）的强抗炎作用是包括急性脊髓损伤（SCI）在内的各种严重病例的必要治疗方法。然而,人们对国会议员的不利影响表示担忧，这也严重限制了其临床应用。天然多酚，由于其丰富的酚羟基化学性质，可以形成动态结构，而无需额外的修改，在病变部位实现靶向富集和药物释放，使他们成为一个非常有前途的载体。考虑到MP的临床应用挑战，天然多酚平台用于MP的靶向和有效递送，减少其全身副作用。体外和SCI模型均证明多酚作为递送MP的载体具有多种优势：（1）在给药后2小时内在受伤部位实现了最大富集，满足了疾病早期治疗的愿望；（2）MP的无痕释放；（3）减少其副作用；（4）赋予治疗系统新的抗氧化特性，这也是疾病治疗需要解决的一个方面。这项研究强调了基于天然多酚的强大传递系统可以成功克服MP治疗障碍的前景，为其广泛的临床应用提供了可能。
