Abstract：
Dietary supplements are widely consumed. However, the lack of mandatory testing results in limited data on their quality, particularly in Eastern Europe. In this study, 21 legally registered and 9 illegal supplements, seized from an underground facility by the Polish Police, were examined. Contaminants were screened by utilising high-performance liquid chromatography coupled with untargeted mass spectrometry. The analysis identified 32 contaminants in the 30 dietary supplements examined. Untargeted analysis revealed a concerning issue: the intentional adulteration of both legal and illegal supplements with pharmacologically active substances that are prohibited in this category of products. This study indicated that many dietary supplements are of low quality due to deliberate adulteration or inadequate manufacturing conditions. The presence of unregistered or unapproved substances in these supplements poses serious health risks. Strong legal regulations are essential to address this issue effectively.
摘要：
膳食补充剂被广泛食用。然而,在有限的质量数据中缺乏强制性测试结果，尤其是在东欧。在这项研究中,21个合法注册和9个非法补充剂，波兰警方从地下设施中查获,进行了检查。通过利用高效液相色谱和非靶向质谱联用来筛选污染物。分析确定了所检查的30种膳食补充剂中的32种污染物。无针对性的分析揭示了一个令人担忧的问题：故意将合法和非法补充剂与此类产品中禁止的药理活性物质掺假。这项研究表明，由于故意掺假或制造条件不足，许多膳食补充剂的质量较低。这些补充剂中存在未注册或未经批准的物质会带来严重的健康风险。强有力的法律法规对于有效解决这一问题至关重要。
