Abstract：
Aluminum oxide nanoparticles (Al2O3 NPs) are among the most extensively utilized nanoparticles in nanotechnology and that have negative impacts on the environment. Therefore, the intention of this work is to investigate the protective and therapeutic effects of curcumin in nanoform (Cur NPs) against Al2O3 NPs induced kidney toxicity, oxidative stress, DNA damage, and changes in necrosis factor alpha (TNFα) and proliferating cell nuclear antigen (PCNA) expressions in male rats. Fifty healthy adult male were divided into five groups [G1, control; G2, received 50 mg/kg/day for 4 weeks of Cur NPs orally; G3, received 6 mg/kg BW orally for 4 weeks of Al2O3 NPs; G4, (Cur NPs + Al2O3 NPs) received Cur NPs and Al2O3 NPs at a dose similar to G2 and G3, respectively for 4 weeks; G5, (Al2O3 NPs + Cur NPs) received Al2O3 NPs at a dose similar to G3 for 4 weeks then received Cur NPs at a dose similar to G2 for another 4 weeks]. Current results revealed that Al2O3 NPs induced a significant elevation in serum urea, creatinine, chloride, calcium, kidney malondialdehyde (MDA), DNA damage, injury, TNFα and PCNA expressions and a significant depletion in serum potassium, kidney superoxide dismutase (SOD), glutathione (GSH) as compared to control. On the other hand, treatments of Al2O3 NPs with Cur NPs induced modulation in all altered parameters and improved kidney functions and structure, with best results for the Al2O3 NPs + Cur NPs than Cur NPs + Al2O3 NPs. In conclusion, Cur NPs has the capacity to mitigate the renal toxicity induced by Al2O3 NPs in male albino rats.
摘要：
氧化铝纳米颗粒（Al2O3NPs）是纳米技术中使用最广泛的纳米颗粒之一，对环境有负面影响。因此,这项工作的目的是研究纳米形式的姜黄素（CurNPs）对Al2O3NPs诱导的肾毒性的保护和治疗作用，氧化应激，DNA损伤,以及雄性大鼠坏死因子α（TNFα）和增殖细胞核抗原（PCNA）表达的变化。将50名健康成年男性分为五组[G1，对照组；G2，口服50mg/kg/天，持续4周的CurNPs；G3，口服6mg/kgBW，持续4周的Al2O3NPs；G4（CurNPsAl2O3NPs）分别以类似于G2和G3的剂量接受CurNPs和Al2O3NPs，持续4周；G5，（以类似的剂量接受另一个G3接受4周的目前的结果表明，Al2O3NP诱导血清尿素显著升高，肌酐,氯化物,钙，肾脏丙二醛（MDA），DNA损伤,损伤,TNFα和PCNA的表达和血清钾的显着消耗，肾超氧化物歧化酶（SOD），谷胱甘肽(GSH)与对照相比。另一方面,用CurNPs处理Al2O3NPs可诱导所有参数的调节，并改善肾功能和结构，Al2O3NP+CurNP的结果比CurNP+Al2O3NP的结果最好。总之,CurNP具有减轻雄性白化病大鼠中Al2O3NP诱导的肾毒性的能力。
