Abstract：
OBJECTIVE: This study aimed to compare the efficacy of topical 5% Sodium Chloride (NaCl) and 10% Mannitol agents in managing corneal edema following uncomplicated cataract surgery.
METHODS: Patients with postoperative corneal edema were enrolled, and they were divided into three groups for comparison. Anterior chamber depth (ACD), axial length (AL), intraocular lens (IOL) power, cumulative dissipated energy (CDE), best-corrected visual acuity (BCVA), central corneal thickness (CCT), and endothelial cell count (ECC) were assessed among the groups.
RESULTS: Fifty-eight eyes of 58 patients were included. The study comprised the NaCl group (using topical 5% NaCl, n = 21), Mannitol group (using topical 10% Mannitol, n = 17), and a control group without osmotic agent use (n = 20). Age, gender, ACD, AL, IOL power, and CDE were similar across groups. Postoperative day-1 CCT values showed no significant difference between groups. Additionally, at postoperative 1 week, CCT values were [663.4 ± 100.2] microns in the NaCl group, [640.4 ± 68.9] microns in the Mannitol group, and [760.3 ± 76.7] microns in the Control group. Although CCT and BCVA values were better in the Mannitol group at postoperative 1 week, no statistically significant difference was found between the groups at 1 week and 1 month postoperatively. Furthermore, corneal edema positively correlated with CDE and negatively correlated with AL.
CONCLUSIONS: Topical 5% NaCl and 10% Mannitol agents are effective and reliable agents that showed faster recovery of corneal edema during the early postoperative period after uncomplicated cataract surgery. The choice between these agents may depend on factors such as patient tolerability, cost, and availability.
METHODS: Patients with postoperative corneal edema were enrolled, and they were divided into three groups for comparison. Anterior chamber depth (ACD), axial length (AL), intraocular lens (IOL) power, cumulative dissipated energy (CDE), best-corrected visual acuity (BCVA), central corneal thickness (CCT), and endothelial cell count (ECC) were assessed among the groups.
RESULTS: Fifty-eight eyes of 58 patients were included. The study comprised the NaCl group (using topical 5% NaCl, n = 21), Mannitol group (using topical 10% Mannitol, n = 17), and a control group without osmotic agent use (n = 20). Age, gender, ACD, AL, IOL power, and CDE were similar across groups. Postoperative day-1 CCT values showed no significant difference between groups. Additionally, at postoperative 1 week, CCT values were [663.4 ± 100.2] microns in the NaCl group, [640.4 ± 68.9] microns in the Mannitol group, and [760.3 ± 76.7] microns in the Control group. Although CCT and BCVA values were better in the Mannitol group at postoperative 1 week, no statistically significant difference was found between the groups at 1 week and 1 month postoperatively. Furthermore, corneal edema positively correlated with CDE and negatively correlated with AL.
CONCLUSIONS: Topical 5% NaCl and 10% Mannitol agents are effective and reliable agents that showed faster recovery of corneal edema during the early postoperative period after uncomplicated cataract surgery. The choice between these agents may depend on factors such as patient tolerability, cost, and availability.
摘要：
目的：本研究旨在比较5％氯化钠（NaCl）和10％甘露醇外用药物治疗无并发症白内障手术后角膜水肿的疗效。
方法：纳入术后角膜水肿患者，他们被分成三组进行比较。前房深度（ACD），轴向长度（AL），人工晶状体（IOL）功率，累积耗散能量(CDE)，最佳矫正视力（BCVA），中央角膜厚度(CCT),和内皮细胞计数（ECC）进行评估。
结果：纳入58例患者的58只眼。该研究包括NaCl组(使用局部5%NaCl，n=21),甘露醇组（使用外用10%甘露醇，n=17),对照组不使用渗透剂(n=20)。年龄,性别,ACD,AL,IOL功率,各组CDE相似。术后第1天CCT值组间无显著差异。此外,术后1周,NaCl组CCT值为[663.4±100.2]微米,甘露醇组中的[640.4±68.9]微米，对照组为[760.3±76.7]微米。尽管在术后1周时甘露醇组的CCT和BCVA值更好,术后1周和1个月两组间差异无统计学意义.此外，角膜水肿与CDE呈正相关,与AL呈负相关。
结论：外用5%NaCl和10%甘露醇药是有效和可靠的药物，在无并发症的白内障手术后早期显示角膜水肿恢复更快。这些药物之间的选择可能取决于患者的耐受性等因素，成本,和可用性。
方法：纳入术后角膜水肿患者，他们被分成三组进行比较。前房深度（ACD），轴向长度（AL），人工晶状体（IOL）功率，累积耗散能量(CDE)，最佳矫正视力（BCVA），中央角膜厚度(CCT),和内皮细胞计数（ECC）进行评估。
结果：纳入58例患者的58只眼。该研究包括NaCl组(使用局部5%NaCl，n=21),甘露醇组（使用外用10%甘露醇，n=17),对照组不使用渗透剂(n=20)。年龄,性别,ACD,AL,IOL功率,各组CDE相似。术后第1天CCT值组间无显著差异。此外,术后1周,NaCl组CCT值为[663.4±100.2]微米,甘露醇组中的[640.4±68.9]微米，对照组为[760.3±76.7]微米。尽管在术后1周时甘露醇组的CCT和BCVA值更好,术后1周和1个月两组间差异无统计学意义.此外，角膜水肿与CDE呈正相关,与AL呈负相关。
结论：外用5%NaCl和10%甘露醇药是有效和可靠的药物，在无并发症的白内障手术后早期显示角膜水肿恢复更快。这些药物之间的选择可能取决于患者的耐受性等因素，成本,和可用性。
