PDF(Pubmed)
Abstract：
UNASSIGNED: The percentage of shunt fraction significantly impacts the management of patients with congenital shunts, influencing strategic choices such as surgical or interventional procedures. This study compared the estimated shunt fraction (the ratio of pulmonary-to-systemic flow, Qp/Qs) for quantifying the left-to-right shunt in children with ventricular septal defect (VSD) using heart catheterization, four-dimensional (4D) flow, and two-dimensional (2D) flow magnetic resonance imaging (MRI). The goal was to establish a non-invasive and reliable measurement ratio between pulmonary and systemic blood flow in these patients.
UNASSIGNED: Between July 2022 and June 2023, patients scheduled to undergo invasive right heart catheterization were included in this study. MRI was performed one hour before the catheterization procedure. The correlation of shunt fraction was assessed between all methods after calculating the Qp/Qs ratio from 2D and 4D flow MRI and catheterization.
UNASSIGNED: A total of 24 patients (aged 3-15 years, eight females) were ultimately included in the study. The Qp/Qs ratios obtained from 4D flow had a robust correlation (correlation coefficient r = 0.962) compared to those obtained during catheterization. Cardiac catheterization recorded the mean shunt fraction at 1.499 ± 0.396, while 4D flow measured it at 1.403 ± 0.344, with no significant difference between the two techniques. Moreover, there was a reasonable correlation (r = 0.894) between 2D flow measurements of Qp/Qs and the results obtained from catheterization, with a mean shunt fraction of 1.326 ± 0.283.
UNASSIGNED: 4D flow MRI has the potential to be a non-invasive method for accurately measuring the left-to-right shunt in children with VSD.
UNASSIGNED: Between July 2022 and June 2023, patients scheduled to undergo invasive right heart catheterization were included in this study. MRI was performed one hour before the catheterization procedure. The correlation of shunt fraction was assessed between all methods after calculating the Qp/Qs ratio from 2D and 4D flow MRI and catheterization.
UNASSIGNED: A total of 24 patients (aged 3-15 years, eight females) were ultimately included in the study. The Qp/Qs ratios obtained from 4D flow had a robust correlation (correlation coefficient r = 0.962) compared to those obtained during catheterization. Cardiac catheterization recorded the mean shunt fraction at 1.499 ± 0.396, while 4D flow measured it at 1.403 ± 0.344, with no significant difference between the two techniques. Moreover, there was a reasonable correlation (r = 0.894) between 2D flow measurements of Qp/Qs and the results obtained from catheterization, with a mean shunt fraction of 1.326 ± 0.283.
UNASSIGNED: 4D flow MRI has the potential to be a non-invasive method for accurately measuring the left-to-right shunt in children with VSD.
摘要：
■分流部分的百分比显着影响先天性分流患者的管理，影响战略选择，如手术或介入程序。这项研究比较了估计的分流分数（肺与全身流量的比率，Qp/Qs）用于使用心导管术量化室间隔缺损（VSD）儿童的左向右分流，四维（4D）流，和二维（2D）流磁共振成像（MRI）。目标是在这些患者的肺和全身血流量之间建立非侵入性且可靠的测量比率。
■在2022年7月至2023年6月之间，计划接受侵入性右心导管插入术的患者被纳入本研究。在导管插入程序前1小时进行MRI。从2D和4D流MRI和导管插入术计算Qp/Qs比值后，评估了所有方法之间分流分数的相关性。
■共有24名患者（3-15岁，八名女性)最终被纳入研究。与导管插入期间获得的那些相比,从4D流获得的Qp/Qs比率具有稳健的相关性(相关系数r=0.962)。心导管检查记录的平均分流分数为1.499±0.396，而4D流量测量为1.403±0.344，两种技术之间没有显着差异。此外，Qp/Qs的2D流量测量与导管插入术获得的结果之间存在合理的相关性（r=0.894），平均分流分数为1.326±0.283。
■4D流量MRI有可能成为一种无创的方法，用于精确测量VSD患儿的左右分流。
■在2022年7月至2023年6月之间，计划接受侵入性右心导管插入术的患者被纳入本研究。在导管插入程序前1小时进行MRI。从2D和4D流MRI和导管插入术计算Qp/Qs比值后，评估了所有方法之间分流分数的相关性。
■共有24名患者（3-15岁，八名女性)最终被纳入研究。与导管插入期间获得的那些相比,从4D流获得的Qp/Qs比率具有稳健的相关性(相关系数r=0.962)。心导管检查记录的平均分流分数为1.499±0.396，而4D流量测量为1.403±0.344，两种技术之间没有显着差异。此外，Qp/Qs的2D流量测量与导管插入术获得的结果之间存在合理的相关性（r=0.894），平均分流分数为1.326±0.283。
■4D流量MRI有可能成为一种无创的方法，用于精确测量VSD患儿的左右分流。
