PDF(Pubmed)
Abstract：
Drug reactions with eosinophilia and systemic symptoms (DRESS) syndrome and Stevens-Johnson syndrome-toxic epidermal necrolysis (SJS-TEN) are reactive entities of aberrant cytotoxic immunologic reactions to exogenous medications. While they are conventionally seen as distinct, separate conditions, we present a case of a rare evolution of DRESS syndrome into SJS-TEN in the setting of simultaneous amoxicillin-clavulanate initiation and long-term sildenafil use in a 66-year-old South Asian female with a known history of prior DRESS syndrome and pulmonary arterial hypertension. We discuss the conditions leading to her unique clinical presentation and provide considerations for future clinical encounters.
摘要：
具有嗜酸性粒细胞增多和全身症状（DRESS）综合征和史蒂文斯-约翰逊综合征毒性表皮坏死松解症（SJS-TEN）的药物反应是对外源性药物的异常细胞毒性免疫反应的反应性实体。虽然它们通常被认为是不同的，单独的条件,我们介绍了一例在阿莫西林-克拉维酸同时开始使用和长期使用西地那非的情况下,DRESS综合征罕见地演变为SJS-TEN的病例,一名66岁的南亚女性有DRESS综合征和肺动脉高压的既往病史.我们讨论了导致她独特临床表现的条件，并为将来的临床遇到提供了考虑因素。
