PDF(Pubmed)
Abstract：
Biliary atresia (BA) is a progressive fibroinflammatory disease affecting both the extrahepatic and intrahepatic bile ducts, potentially leading to chronic cholestasis and biliary cirrhosis. Despite its prevalence, the exact mechanisms behind BA development remain incompletely understood. Recent research suggests that the gut microbiota and its metabolites may play significant roles in BA development. This paper offers a comprehensive review of the changing characteristics of gut microbiota and their metabolites at different stages of BA in children. It discusses their influence on the host\'s inflammatory response, immune system, and bile acid metabolism. The review also explores the potential of gut microbiota and metabolites as a therapeutic target for BA, with interventions like butyrate and gut microbiota preparations showing promise in alleviating BA symptoms. While progress has been made, further research is necessary to untangle the complex interactions between gut microbiota and BA, paving the way for more effective prevention and treatment strategies for this challenging condition.
摘要：
胆道闭锁（BA）是一种进行性纤维炎性疾病，影响肝外和肝内胆管，可能导致慢性胆汁淤积和胆汁性肝硬化。尽管流行,BA发展背后的确切机制仍未完全理解。最近的研究表明，肠道菌群及其代谢产物可能在BA的发育中起重要作用。本文对儿童BA不同阶段肠道菌群及其代谢产物的变化特征进行了全面综述。它讨论了它们对宿主的炎症反应的影响，免疫系统,和胆汁酸代谢。该综述还探讨了肠道微生物群和代谢物作为BA治疗靶标的潜力，丁酸盐和肠道菌群制剂等干预措施有望缓解BA症状。虽然取得了进展，需要进一步的研究来解开肠道微生物群和BA之间复杂的相互作用，为更有效地预防和治疗这种具有挑战性的疾病铺平了道路。
