PDF(Pubmed)
Abstract：
Observational studies have linked autoimmune diseases (ADs) with rhinosinusitis (RS) manifestations. To establish a causal relationship between ADs and RS, and to explore the potential mediating role of inflammatory mediators between ADs and RS, we utilized Mendelian randomization (MR) analysis. Using a two-sample MR methodology, we examined the causality between multiple sclerosis (MS), rheumatoid arthritis (RA), ankylosing spondylitis (AS), psoriasis (PsO), type 1 diabetes (T1D), Sjogren\'s syndrome (SS), celiac disease (CeD), Crohn\'s disease (CD), hypothyroidism (HT), Graves\' disease (GD), and Hashimoto\'s thyroiditis and their association with chronic and acute rhinosinusitis (CRS and ARS, respectively).To achieve this, we employed three distinct MR techniques: inverse variance weighting (IVW), MR-Egger, and the weighted median method. Our analysis also included a variety of sensitivity assessments, such as Cochran\'s Q test, leave-one-out analysis, MR-Egger intercept, and MR-PRESSO, to ensure the robustness of our findings. Additionally, the study explored the role of inflammation proteins as a mediator in these relationships through a comprehensive two-step MR analysis. Among the ADs, MS, RA, T1D, CeD, and HT were determined as risk factors for CRS. Only CeD exhibited a causal relationship with ARS. Subsequent analyses identified interleukin-10 (IL-10) as a potential mediator for the association of MS, RA and HT with CRS, respectively., while C-X-C motif chemokine 10 levels (CXCL10) and T-cell surface glycoprotein CD6 isoform levels (CD6) were found to influence HT\'s effect on CRS. Our findings demonstrate a causative link between specific autoimmune diseases and rhinosinusitis, highlighting IL-10, CXCL10, and CD6 as potential mediators in this association.
摘要：
观察性研究已将自身免疫性疾病（AD）与鼻窦炎（RS）表现联系起来。建立AD和RS之间的因果关系，探讨炎症介质在AD和RS之间的潜在中介作用,我们利用孟德尔随机化(MR)分析.使用双样本MR方法，我们检查了多发性硬化症(MS)之间的因果关系，类风湿性关节炎(RA),强直性脊柱炎（AS），牛皮癣（PsO），1型糖尿病（T1D），干燥综合征（SS），乳糜泻（CeD），克罗恩病（CD），甲状腺功能减退症(HT),严重疾病（GD），和桥本甲状腺炎及其与慢性和急性鼻-鼻窦炎(CRS和ARS，分别)。为了实现这一点，我们采用了三种不同的MR技术：方差逆加权(IVW)，MR-Egger,和加权中位数法。我们的分析还包括各种敏感性评估，例如Cochran的Q测试，遗漏分析，MR-Egger截获,和MR-PRESSO,以确保我们研究结果的稳健性。此外,该研究通过全面的两步MR分析探索了炎症蛋白在这些关系中作为介质的作用.在广告中，MS,RA,T1D,CeD,和HT被确定为CRS的危险因素。只有CeD表现出与ARS的因果关系。随后的分析确定白细胞介素-10（IL-10）是MS关联的潜在介质，RA和HT与CRS，分别。,发现C-X-C基序趋化因子10水平（CXCL10）和T细胞表面糖蛋白CD6同工型水平（CD6）影响HT对CRS的作用。我们的发现证明了特异性自身免疫性疾病和鼻窦炎之间的因果关系。强调IL-10、CXCL10和CD6是这种关联的潜在介质。
