PDF(Pubmed)
Abstract：
UNASSIGNED: Globally, diet low in milk is the third greatest risk factor for colorectal cancer (CRC). However, there has been a lack of detailed worldwide analysis of the burden and trends of CRC attributable to diet low in milk.
UNASSIGNED: We aim to assess the spatiotemporal trends of CRC-related mortality and disability-adjusted life-years (DALYs) attributable to diet low in milk at the global, regional, and national levels from 1990 to 2019.
UNASSIGNED: Data of mortality, DALYs, age-standardized mortality rate (ASMR), and age-standardized DALY rate (ASDR) of CRC attributable to diet low in milk were extracted from the Global Burden of Disease (GBD) 2019 study. The burden of CRC attributable to diet low in milk was estimated using the ASMR and ASDR, while accounting for sex, age, country, and socio-demographic index (SDI). From 1990 to 2019, the estimated annual percentage change (EAPC) was calculated to clarify the temporal trends in the ASMR and ASDR attributable to diet low in milk.
UNASSIGNED: In 2019, there were 166,456 (95% UI = 107,221-226,027) deaths and 3,799,297 (95% UI = 2,457,768-5,124,453) DALYs attributable to diet low in milk, accounting for 15.3 and 15.6% of CRC-related deaths and DALYs in 2019. CRC-related deaths and DALYs attributed to diet low in milk increased by 130.5 and 115.4%, from 1990 to 2019. The burden of CRC attributable to diet low in milk varied notably among regions and nations. High-middle SDI regions had the highest ASDR and ASMR of CRC linked to diet low in milk, while there was a slight downward trend high SDI regions. Among geographical regions, East Asia had the highest number of CRC-related deaths and DALYs attributable to diet low in milk. Notably, the burden of CRC was highest in males and the elderly. With coefficients of -0.36 and -0.36, the EAPC in ASMR and ASDR was significantly inversely correlated with the Human Development Index in 2019.
UNASSIGNED: Globally, the number of CRC deaths attributable to diet low in milk has continued to increase over the last 30 years. Therefore, government and authorities should conduct education campaigns to encourage individuals to increase daily milk intake.
UNASSIGNED: We aim to assess the spatiotemporal trends of CRC-related mortality and disability-adjusted life-years (DALYs) attributable to diet low in milk at the global, regional, and national levels from 1990 to 2019.
UNASSIGNED: Data of mortality, DALYs, age-standardized mortality rate (ASMR), and age-standardized DALY rate (ASDR) of CRC attributable to diet low in milk were extracted from the Global Burden of Disease (GBD) 2019 study. The burden of CRC attributable to diet low in milk was estimated using the ASMR and ASDR, while accounting for sex, age, country, and socio-demographic index (SDI). From 1990 to 2019, the estimated annual percentage change (EAPC) was calculated to clarify the temporal trends in the ASMR and ASDR attributable to diet low in milk.
UNASSIGNED: In 2019, there were 166,456 (95% UI = 107,221-226,027) deaths and 3,799,297 (95% UI = 2,457,768-5,124,453) DALYs attributable to diet low in milk, accounting for 15.3 and 15.6% of CRC-related deaths and DALYs in 2019. CRC-related deaths and DALYs attributed to diet low in milk increased by 130.5 and 115.4%, from 1990 to 2019. The burden of CRC attributable to diet low in milk varied notably among regions and nations. High-middle SDI regions had the highest ASDR and ASMR of CRC linked to diet low in milk, while there was a slight downward trend high SDI regions. Among geographical regions, East Asia had the highest number of CRC-related deaths and DALYs attributable to diet low in milk. Notably, the burden of CRC was highest in males and the elderly. With coefficients of -0.36 and -0.36, the EAPC in ASMR and ASDR was significantly inversely correlated with the Human Development Index in 2019.
UNASSIGNED: Globally, the number of CRC deaths attributable to diet low in milk has continued to increase over the last 30 years. Therefore, government and authorities should conduct education campaigns to encourage individuals to increase daily milk intake.
摘要：
■全球，低奶饮食是结直肠癌（CRC）的第三大危险因素。然而,对于低奶饮食导致的CRC的负担和趋势,缺乏详细的全球分析.
我们的目标是评估全球因低牛奶饮食导致的CRC相关死亡率和残疾调整寿命年（DALYs）的时空趋势。区域,从1990年到2019年的全国水平。
■死亡率数据，DALYs,年龄标准化死亡率(ASMR)，和归因于低奶饮食的CRC的年龄标准化DALY率(ASDR)来自全球疾病负担(GBD)2019研究.使用ASMR和ASDR估计归因于低牛奶饮食的CRC负担，在考虑性别的同时，年龄,国家,社会人口指数（SDI）。从1990年到2019年，计算了估计的年度百分比变化（EAPC），以阐明归因于低牛奶饮食的ASMR和ASDR的时间趋势。
■在2019年，有166,456（95％UI=107,221-226,027）死亡和3,799,297（95％UI=2,457,768-5,124,453）DALYs归因于低奶饮食，占2019年CRC相关死亡和DALYs的15.3%和15.6%。与CRC相关的死亡和归因于低牛奶饮食的DALYs增加了130.5％和115.4％，从1990年到2019年。归因于低牛奶饮食的CRC负担在地区和国家之间差异显著。中高SDI地区的CRCASDR和ASMR最高，与牛奶含量低的饮食有关，而高SDI地区有轻微下降的趋势。在地理区域中，东亚与CRC相关的死亡和DALYs的数量最高，原因是饮食中牛奶含量低。值得注意的是,男性和老年人的CRC负担最高.在-0.36和-0.36的系数下，ASMR和ASDR中的EAPC与2019年的人类发展指数呈显著负相关。
■全球，在过去30年中,由于低奶饮食导致的CRC死亡人数持续增加.因此,政府和当局应开展教育运动，鼓励个人增加每日牛奶摄入量。
我们的目标是评估全球因低牛奶饮食导致的CRC相关死亡率和残疾调整寿命年（DALYs）的时空趋势。区域,从1990年到2019年的全国水平。
■死亡率数据，DALYs,年龄标准化死亡率(ASMR)，和归因于低奶饮食的CRC的年龄标准化DALY率(ASDR)来自全球疾病负担(GBD)2019研究.使用ASMR和ASDR估计归因于低牛奶饮食的CRC负担，在考虑性别的同时，年龄,国家,社会人口指数（SDI）。从1990年到2019年，计算了估计的年度百分比变化（EAPC），以阐明归因于低牛奶饮食的ASMR和ASDR的时间趋势。
■在2019年，有166,456（95％UI=107,221-226,027）死亡和3,799,297（95％UI=2,457,768-5,124,453）DALYs归因于低奶饮食，占2019年CRC相关死亡和DALYs的15.3%和15.6%。与CRC相关的死亡和归因于低牛奶饮食的DALYs增加了130.5％和115.4％，从1990年到2019年。归因于低牛奶饮食的CRC负担在地区和国家之间差异显著。中高SDI地区的CRCASDR和ASMR最高，与牛奶含量低的饮食有关，而高SDI地区有轻微下降的趋势。在地理区域中，东亚与CRC相关的死亡和DALYs的数量最高，原因是饮食中牛奶含量低。值得注意的是,男性和老年人的CRC负担最高.在-0.36和-0.36的系数下，ASMR和ASDR中的EAPC与2019年的人类发展指数呈显著负相关。
■全球，在过去30年中,由于低奶饮食导致的CRC死亡人数持续增加.因此,政府和当局应开展教育运动，鼓励个人增加每日牛奶摄入量。
