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Abstract：
UNASSIGNED: We compared pulmonary function indices and quantitative CT parameters of airway remodeling, air trapping, and emphysema in asthmatic patients and patients with COPD and asthma-COPD overlap (ACO) and explored their relationships with airflow limitation.
UNASSIGNED: Patients with asthma (n=48), COPD (n=52), and ACO (n=30) and controls (n=54) who completed pulmonary function tests and HRCT scans were retrospectively enrolled in our study. Quantitative CT analysis software was used to assess emphysema (LAA%), airway wall dimensions (wall area (WA), luminal area (LA), and wall area percentage (WA%)), and air trapping ((relative volume change of -860 HU to -950 HU (RVC-860 to-950) and the expiration-to-inspiration ratio of the mean lung density (MLDE/I))). Differences in pulmonary function and HRCT parameters were compared among the groups. Spearman correlation analysis and regression analysis were utilized to explore structure‒function relationships.
UNASSIGNED: The LAA% in COPD and ACO patients was significantly greater than that in asthmatic patients and controls. The WA% and WA in COPD and ACO patients were greater than those in controls, whereas the WA% and LA between asthmatic patients and controls reached statistical significance. The RVC-860 to -950 levels decreased in the following order: ACO, COPD, and asthma. RVC-860 to -950 independently predicted FEV1% in asthmatic patients; LAA% and MLDE/I in COPD patients; and LAA%, WA% and RVC-860 to -950 in ACO patients.
UNASSIGNED: Comparable emphysema was observed in patients with COPD and ACO but not in asthmatic patients. All patients exhibited proximal airway remodeling. The bronchi were thickened outward in COPD and ACO patients but are thickened inward in asthmatic patients. Furthermore, air trapping in ACO patients was the most severe among all the groups. Indirect lung densitometry measurements might be more predictive of the degree of airflow limitation than direct airway measurements in obstructive airway diseases.
UNASSIGNED: Patients with asthma (n=48), COPD (n=52), and ACO (n=30) and controls (n=54) who completed pulmonary function tests and HRCT scans were retrospectively enrolled in our study. Quantitative CT analysis software was used to assess emphysema (LAA%), airway wall dimensions (wall area (WA), luminal area (LA), and wall area percentage (WA%)), and air trapping ((relative volume change of -860 HU to -950 HU (RVC-860 to-950) and the expiration-to-inspiration ratio of the mean lung density (MLDE/I))). Differences in pulmonary function and HRCT parameters were compared among the groups. Spearman correlation analysis and regression analysis were utilized to explore structure‒function relationships.
UNASSIGNED: The LAA% in COPD and ACO patients was significantly greater than that in asthmatic patients and controls. The WA% and WA in COPD and ACO patients were greater than those in controls, whereas the WA% and LA between asthmatic patients and controls reached statistical significance. The RVC-860 to -950 levels decreased in the following order: ACO, COPD, and asthma. RVC-860 to -950 independently predicted FEV1% in asthmatic patients; LAA% and MLDE/I in COPD patients; and LAA%, WA% and RVC-860 to -950 in ACO patients.
UNASSIGNED: Comparable emphysema was observed in patients with COPD and ACO but not in asthmatic patients. All patients exhibited proximal airway remodeling. The bronchi were thickened outward in COPD and ACO patients but are thickened inward in asthmatic patients. Furthermore, air trapping in ACO patients was the most severe among all the groups. Indirect lung densitometry measurements might be more predictive of the degree of airflow limitation than direct airway measurements in obstructive airway diseases.
摘要：
■我们比较了气道重塑的肺功能指标和定量CT参数，空气捕集,哮喘患者和COPD和哮喘-COPD重叠（ACO）患者的肺气肿，并探讨了它们与气流受限的关系。
■哮喘患者（n=48），COPD（n=52），以及完成肺功能检查和HRCT扫描的ACO(n=30)和对照组(n=54)被回顾性纳入本研究.定量CT分析软件用于评估肺气肿（LAA％），气道壁尺寸(壁面积(WA)，管腔面积(LA),和墙壁面积百分比(WA%))，和空气截留（（-860HU至-950HU的相对体积变化（RVC-860至-950）和平均肺密度的呼气与吸气比（MLDE/I））。比较各组之间肺功能和HRCT参数的差异。利用Spearman相关分析和回归分析探索结构与功能的关系。
■COPD和ACO患者的LAA%显著高于哮喘患者和对照组。COPD和ACO患者的WA%和WA高于对照组，而哮喘患者和对照组之间的WA％和LA达到统计学意义。RVC-860至-950水平按以下顺序下降：ACO，COPD,和哮喘。RVC-860至-950独立预测哮喘患者的FEV1％；COPD患者的LAA％和MLDE/I；和LAA％，ACO患者的WA%和RVC-860至-950。
■在COPD和ACO患者中观察到相当的肺气肿，但在哮喘患者中未观察到。所有患者均表现为近端气道重塑。COPD和ACO患者的支气管向外增厚，但哮喘患者的支气管向内增厚。此外，ACO患者的空气滞留是所有组中最严重的。在阻塞性气道疾病中，间接肺密度测定法测量可能比直接气道测量更能预测气流受限的程度。
■哮喘患者（n=48），COPD（n=52），以及完成肺功能检查和HRCT扫描的ACO(n=30)和对照组(n=54)被回顾性纳入本研究.定量CT分析软件用于评估肺气肿（LAA％），气道壁尺寸(壁面积(WA)，管腔面积(LA),和墙壁面积百分比(WA%))，和空气截留（（-860HU至-950HU的相对体积变化（RVC-860至-950）和平均肺密度的呼气与吸气比（MLDE/I））。比较各组之间肺功能和HRCT参数的差异。利用Spearman相关分析和回归分析探索结构与功能的关系。
■COPD和ACO患者的LAA%显著高于哮喘患者和对照组。COPD和ACO患者的WA%和WA高于对照组，而哮喘患者和对照组之间的WA％和LA达到统计学意义。RVC-860至-950水平按以下顺序下降：ACO，COPD,和哮喘。RVC-860至-950独立预测哮喘患者的FEV1％；COPD患者的LAA％和MLDE/I；和LAA％，ACO患者的WA%和RVC-860至-950。
■在COPD和ACO患者中观察到相当的肺气肿，但在哮喘患者中未观察到。所有患者均表现为近端气道重塑。COPD和ACO患者的支气管向外增厚，但哮喘患者的支气管向内增厚。此外，ACO患者的空气滞留是所有组中最严重的。在阻塞性气道疾病中，间接肺密度测定法测量可能比直接气道测量更能预测气流受限的程度。
