UNASSIGNED: To assess if chemokines expressed in lesional CSU skin contribute to T cell/mast cell proximity.
UNASSIGNED: Biopsies from lesional CSU skin were compared to biopsies from healthy skin for expression of CCR5 and its ligand CCL3 by CD4+ T cells and mast cells, respectively.
UNASSIGNED: Numbers of CCR5-positive CD4+ T cells in lesional CSU skin were significantly increased as compared to healthy normal skin (p < 0.0001). The number of mast cells expressing CCL3 (ligand for CCR5) in CSU skin was also increased (p < 0.0002) and significant association with T-cell close proximity (p < 0.0001) is noticed.
UNASSIGNED: The close proximity of T cells and mast cells in the skin of severe CSU may be driven, at least in part by increased CCR5 and CCL3 expression. Therapies that target CCL3 interaction with CCR5 should be assessed for their effects in CSU.
■评估病变CSU皮肤中表达的趋化因子是否有助于T细胞/肥大细胞接近。
■将病变CSU皮肤的活检与健康皮肤的活检进行比较,以确定CD4T细胞和肥大细胞表达CCR5及其配体CCL3,分别。
■病灶CSU皮肤中CCR5阳性CD4+T细胞的数量与健康正常皮肤相比显著增加(p<0.0001)。CSU皮肤中表达CCL3(CCR5的配体)的肥大细胞的数量也增加(p<0.0002),并且注意到与T细胞紧密接近的显著关联(p<0.0001)。
■严重CSU的皮肤中T细胞和肥大细胞的紧密接近可能被驱动,至少部分通过增加CCR5和CCL3表达。应评估针对CCL3与CCR5相互作用的疗法在CSU中的效果。