PDF(Pubmed)
Abstract：
BACKGROUND: Psychiatric medications are not efficacious for treating borderline personality disorder (BPD), yet many patients with BPD are prescribed multiple psychiatric medications. This study aimed to (1) characterize psychiatric medication prescribing practices in adolescents with BPD and (2) assess whether demographic features are associated with prescribing practices.
METHODS: This sample was N = 2950 pediatric patients with BPD (ages 10-19) across the U.S. Data came from the NeuroBlu database, which includes data from 30 U.S. healthcare systems and hundreds of hospitals. Poisson regressions and chi-squared tests determined whether gender, race, and ethnicity were associated with (1) number of unique psychiatric medications prescribed and (2) number of unique medication classes prescribed.
RESULTS: Roughly two-thirds (64.85%) of youth were prescribed any medications. Of these youth, 79.40% were prescribed ≥ 2 unique medications and 72.66% were prescribed ≥ 2 unique medications classes. The mean number of unique medications was 3.50 (SD = 2.50). The mean number of unique medication classes was 2.35 (SD = 1.15). The most commonly prescribed medication classes were antidepressants and antipsychotics, which were often prescribed in combination. Poisson regressions showed that boys were prescribed more unique medications (M = 3.67) than girls (M = 3.47). Non-Latinx youth were prescribed significantly more unique medications (M = 44.12) than Latinx youth (M = 3.60, p = .01).
CONCLUSIONS: Results characterize psychiatric medication prescribing practices in youth with BPD. Prescribing practices vary by demographics, such that boys and non-Latinx youth are prescribed more medications than girls and Latinx youth, respectively. These demographic differences suggest that prescribers may treat BPD differently based on patient demographic characteristics.
METHODS: This sample was N = 2950 pediatric patients with BPD (ages 10-19) across the U.S. Data came from the NeuroBlu database, which includes data from 30 U.S. healthcare systems and hundreds of hospitals. Poisson regressions and chi-squared tests determined whether gender, race, and ethnicity were associated with (1) number of unique psychiatric medications prescribed and (2) number of unique medication classes prescribed.
RESULTS: Roughly two-thirds (64.85%) of youth were prescribed any medications. Of these youth, 79.40% were prescribed ≥ 2 unique medications and 72.66% were prescribed ≥ 2 unique medications classes. The mean number of unique medications was 3.50 (SD = 2.50). The mean number of unique medication classes was 2.35 (SD = 1.15). The most commonly prescribed medication classes were antidepressants and antipsychotics, which were often prescribed in combination. Poisson regressions showed that boys were prescribed more unique medications (M = 3.67) than girls (M = 3.47). Non-Latinx youth were prescribed significantly more unique medications (M = 44.12) than Latinx youth (M = 3.60, p = .01).
CONCLUSIONS: Results characterize psychiatric medication prescribing practices in youth with BPD. Prescribing practices vary by demographics, such that boys and non-Latinx youth are prescribed more medications than girls and Latinx youth, respectively. These demographic differences suggest that prescribers may treat BPD differently based on patient demographic characteristics.
摘要：
背景：精神科药物治疗边缘性人格障碍（BPD）无效，然而，许多BPD患者处方多种精神病药物。这项研究旨在（1）表征患有BPD的青少年的精神病药物处方实践，以及（2）评估人口统计学特征是否与处方实践相关。
方法：该样本是美国N=2950名患有BPD的儿科患者（10-19岁），数据来自NeuroBlu数据库，其中包括来自30个美国医疗保健系统和数百家医院的数据。泊松回归和卡方检验确定性别，种族,和种族与(1)处方的独特精神病药物的数量和(2)处方的独特药物类别的数量相关。
结果：大约三分之二（64.85%）的年轻人服用了任何药物。在这些年轻人中，79.40％的处方≥2种独特药物，72.66％的处方≥2种独特药物类别。独特药物的平均数量为3.50（SD=2.50）。独特药物类别的平均数量为2.35（SD=1.15）。最常见的处方药是抗抑郁药和抗精神病药，这通常是组合开的。泊松回归显示，男孩比女孩（M=3.47）服用更多的独特药物（M=3.67）。非拉丁裔青年处方的独特药物（M=44.12）明显多于拉丁裔青年（M=3.60，p=0.01）。
结论：结果描述了患有BPD的年轻人的精神病药物处方实践。处方实践因人口统计学而异，这样男孩和非拉丁裔青年比女孩和拉丁裔青年服用更多的药物，分别。这些人口统计学差异表明，处方者可能会根据患者的人口统计学特征对BPD进行不同的治疗。
方法：该样本是美国N=2950名患有BPD的儿科患者（10-19岁），数据来自NeuroBlu数据库，其中包括来自30个美国医疗保健系统和数百家医院的数据。泊松回归和卡方检验确定性别，种族,和种族与(1)处方的独特精神病药物的数量和(2)处方的独特药物类别的数量相关。
结果：大约三分之二（64.85%）的年轻人服用了任何药物。在这些年轻人中，79.40％的处方≥2种独特药物，72.66％的处方≥2种独特药物类别。独特药物的平均数量为3.50（SD=2.50）。独特药物类别的平均数量为2.35（SD=1.15）。最常见的处方药是抗抑郁药和抗精神病药，这通常是组合开的。泊松回归显示，男孩比女孩（M=3.47）服用更多的独特药物（M=3.67）。非拉丁裔青年处方的独特药物（M=44.12）明显多于拉丁裔青年（M=3.60，p=0.01）。
结论：结果描述了患有BPD的年轻人的精神病药物处方实践。处方实践因人口统计学而异，这样男孩和非拉丁裔青年比女孩和拉丁裔青年服用更多的药物，分别。这些人口统计学差异表明，处方者可能会根据患者的人口统计学特征对BPD进行不同的治疗。
